Technology Process of 16-Hydroxyequilenin
There total 4 articles about 16-Hydroxyequilenin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
equilin;
With
copper(ll) bromide;
In
chloroform; ethyl acetate;
for 2h;
Heating;
With
sodium hydroxide;
In
water; N,N-dimethyl-formamide;
at 20 ℃;
for 1.5h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ol016224j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 49 percent / pyridinium p-toluenesulfonate / 1 h / Heating
2: 95 percent / m-chloroperbenzoic acid / CHCl3 / 3 h / Ambient temperature
3: 70 percent / 12 M H2SO4 / methanol / 1.5 h / 50 °C
With
sulfuric acid; pyridinium p-toluenesulfonate; 3-chloro-benzenecarboperoxoic acid;
In
methanol; chloroform;
DOI:10.1016/0039-128X(90)90039-E
