ETHYL (R)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE

Base Information

• Chemical Name: ETHYL (R)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE
• CAS No.: 85571-85-3
• Molecular Formula: C6H9 F3 O3
• Molecular Weight: 186.131
• Hs Code.: 2918199090
• Mol file: 85571-85-3.mol

Synonyms:Butanoicacid, 4,4,4-trifluoro-3-hydroxy-, ethyl ester, (R)-;(3R)-4,4,4-Trifluoro-3-hydroxybutanoic acid ethyl ester; Ethyl(R)-4,4,4-trifluoro-3-hydroxybutanoate

Chemical Property of ETHYL (R)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE

Chemical Property:

• Appearance/Colour: colorless,clear liquid
• Vapor Pressure: 0.0496mmHg at 25°C
• Refractive Index: n20/D 1.375(lit.)
• Boiling Point: 88-90 °C21 mm Hg(lit.)
• Flash Point: 186 °F
• PSA: 46.53000
• Density: 1.259 g/mL at 25 °C(lit.)
• LogP: 0.86280

Purity/Quality:

97% ^*data from raw suppliers

ETHYL (R)-(+)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ETHYL (R)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE

There total 4 articles about ETHYL (R)-4,4,4-TRIFLUORO-3-HYDROXYBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → Ethyl (R)-3-hydroxybutanoate (24915-95-5) + ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate (372-30-5,85571-85-3,88968-78-9,99437-70-4) + ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate (85571-85-3)

Guidance literature:

With Fala baker' yeast; allyl alcohol; Microbiological reaction;

DOI:10.1016/S0040-4039(00)02240-1

Reference yield: 62.0%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → Ethyl (R)-3-hydroxybutanoate (24915-95-5) + ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate (372-30-5,85571-85-3,88968-78-9,99437-70-4) + ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate (85571-85-3)

Guidance literature:

With Fala baker' yeast; allyl alcohol; Microbiological reaction;

DOI:10.1016/S0040-4039(00)02240-1

Reference yield:

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → Ethyl (R)-3-hydroxybutanoate (24915-95-5) + ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate (372-30-5,85571-85-3,88968-78-9,99437-70-4) + ethyl acetoacetate (141-97-9) + ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate (85571-85-3)

Guidance literature:

With Fala baker' yeast; allyl alcohol;

DOI:10.1016/S0040-4039(00)02240-1

upstream raw materials:

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

(R)-4,4,4-trifluoro-3-hydroxybutanoic acid

(2R,3R)-4,4,4-Trifluor-3-hydroxy-2-phenylbuttersaeure-ethylester

(R)-4,4,4-trifluorobutane-1,3-diol

Refernces