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High purity Ethyl 4,4,4-trifluoroacetoacetate 98% TOP1 supplier in China
Cas No: 372-31-6
No Data 100 Gram Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Ethyl 4,4,4-trifluoroacetoacetate
Cas No: 372-31-6
No Data 50 Gram 100 Metric Ton/Month Hebei miaobian Biotechnology Co., Ltd Contact Supplier
Ethyl 4,4,4-trifluoroacetoacetate
Cas No: 372-31-6
No Data 50 Gram 50 Metric Ton/Day Zhejiang Haizhou Pharmaceutical Co., Ltd. Contact Supplier
High quality Ethyl 4,4,4-Trifluoroacetoacetate supplier in China
Cas No: 372-31-6
No Data No Data 30 Metric Ton/Month Simagchem Corporation Contact Supplier
ethyl 4,4,4-trifluoroacetoacetate
Cas No: 372-31-6
USD $ 100.0-100.0 / Metric Ton 1 Metric Ton 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Factory supply Ethyl trifluoroacetoacetate
Cas No: 372-31-6
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
372-31-6, safety clearance 99% Ethyl trifluoroacetoacetate from China manufacturer and seller
Cas No: 372-31-6
USD $ 3.0-5.0 / Gram 100 Gram 1000 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
ETFAA
Cas No: 372-31-6
No Data 1 Kilogram 3000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Ethyl 3-oxo-4,4,4-trifluoroacetoacetate
Cas No: 372-31-6
USD $ 2.0-3.0 / Kilogram 1 Kilogram 50 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
Ethyl 4,4,4-trifluoroacetoacetate
Cas No: 372-31-6
No Data No Data 20 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier

372-31-6 Usage

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Chemical Properties

Clear liquid

Uses

4,4,4-Trifluoro-3-oxobutanoic Acid Ethyl Ester is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.
InChI:InChI=1/C6H7F3O3/c1-2-12-5(11)3-4(10)6(7,8)9/h2-3H2,1H3

372-31-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A13717)  Ethyl trifluoroacetoacetate, 98+%    372-31-6 250g 3506.0CNY Detail
Alfa Aesar (A13717)  Ethyl trifluoroacetoacetate, 98+%    372-31-6 50g 1510.0CNY Detail
Alfa Aesar (A13717)  Ethyl trifluoroacetoacetate, 98+%    372-31-6 10g 412.0CNY Detail
TCI America (T0810)  Ethyl 4,4,4-Trifluoroacetoacetate  >98.0%(GC) 372-31-6 500g 2,760.00CNY Detail
TCI America (T0810)  Ethyl 4,4,4-Trifluoroacetoacetate  >98.0%(GC) 372-31-6 100g 690.00CNY Detail
TCI America (T0810)  Ethyl 4,4,4-Trifluoroacetoacetate  >98.0%(GC) 372-31-6 25g 260.00CNY Detail

372-31-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 4,4,4-trifluoroacetoacetate

1.2 Other means of identification

Product number -
Other names Ethyl4,4,-Trifluoroacetoacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:372-31-6 SDS

372-31-6Synthetic route

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

ethyl acetate
141-78-6

ethyl acetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride In diethyl ether; paraffin reflux, 2 h and r.t., 12 h;85%
Stage #1: ethyl acetate With sodium ethanolate at 0 - 5℃; for 1h;
Stage #2: ethyl trifluoroacetate, at 0 - 65℃; for 25h;
70.7%
With diethyl ether; sodium ethanolate
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

trimethylsilyl trifluoroacetate
400-53-3

trimethylsilyl trifluoroacetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium In tetrahydrofuran
Stage #2: trimethylsilyl trifluoroacetate In tetrahydrofuran
Stage #3: With hydrogenchloride In tetrahydrofuran Further stages.;
55%
With n-butyllithium 1.) THF, -78 deg C, 20 min, 2.) THF, RT, 5 h; Yield given. Multistep reaction;
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride
Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon
652-71-1

Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With quinoline In ethanol
3-acetoxy-4,4,4-trifluoro-but-2-enoic acid ethyl ester
2707-65-5

3-acetoxy-4,4,4-trifluoro-but-2-enoic acid ethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

ethyl acetate
141-78-6

ethyl acetate

A

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With ethanol; sulfuric acid; sodium at 90℃; for 48h; Heating;
With sodium ethanolate In ethanol for 48h; Heating;
3-tert-Butylperoxy-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester
129657-54-1

3-tert-Butylperoxy-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester

A

tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In tetrachloromethane at 20℃; Equilibrium constant; Rate constant;
ethanol
64-17-5

ethanol

2,2-Dimethyl-5-(2,2,2-trifluoro-1-hydroxy-ethylidene)-[1,3]dioxane-4,6-dione
693817-83-3

2,2-Dimethyl-5-(2,2,2-trifluoro-1-hydroxy-ethylidene)-[1,3]dioxane-4,6-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
at 70℃; for 6h; Ring cleavage; Decarboxylation;
ethyl acetate
141-78-6

ethyl acetate

sodium compound of orthotrifluoroacetic acid diethyl ester

sodium compound of orthotrifluoroacetic acid diethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

diethyl ether
60-29-7

diethyl ether

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

sodium

sodium

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

A

ethyl 3-trifluoromethyl-3-oxo-propionate
106260-08-6

ethyl 3-trifluoromethyl-3-oxo-propionate

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In tetrahydrofuran-d8 Equilibrium constant;
ethyl 3-trifluoromethyl-3-oxo-propionate
106260-08-6

ethyl 3-trifluoromethyl-3-oxo-propionate

A

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With water In tetrahydrofuran-d8 Equilibrium constant;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

Trifluoroacetaldehyde ethyl hemiacetal
433-27-2

Trifluoroacetaldehyde ethyl hemiacetal

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Stage #1: ethyl trifluoroacetaldehyde hemiacetal With sulfuric acid at 70 - 150℃; for 0.133333h; microwave irradiation;
Stage #2: diazoacetic acid ethyl ester In dichloromethane at 20℃; for 0.25h; Further stages.;
15 % Chromat.
ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate
18955-75-4

ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diisopropyl ether
2: H2O; methanol / Heating
3: quinoline / ethanol
View Scheme
Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-(2)
2559-41-3

Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-(2)

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O; methanol / Heating
2: quinoline / ethanol
View Scheme
sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate
22466-45-1

sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With hydrogenchloride In water at 5 - 10℃; for 3h; pH=1 - 3;
1,1,1-trifluoro-2-propanone
421-50-1

1,1,1-trifluoro-2-propanone

Diethyl carbonate
105-58-8

Diethyl carbonate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride In toluene Inert atmosphere; Reflux;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

N-(4-hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-guanidine

N-(4-hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-guanidine

Conditions
ConditionsYield
Stage #1: biguanide sulfate With sodium hydroxide In ethanol at 0 - 20℃;
Stage #2: ethyl 4,4,4-trifluoroacetoacetate In ethanol for 2.5h; Heating; Further stages.;
100%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 4,4,4-trifluoroacetoacetate
83097-87-4

benzyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In toluene at 120℃; for 5h; Dean-Stark;100%
In toluene Heating;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(2-hydroxy-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one
68761-48-8

4-(2-hydroxy-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

5-ethoxylcarbonyl-6-hydroxy-4-(2-hydroxyphenyl)-1-phenyl-3-methyl-6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran

5-ethoxylcarbonyl-6-hydroxy-4-(2-hydroxyphenyl)-1-phenyl-3-methyl-6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran

Conditions
ConditionsYield
With ammonium acetate In ethanol at 20℃; for 2h;100%
aluminum ethoxide
555-75-9

aluminum ethoxide

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

acetylacetone
123-54-6

acetylacetone

monoacetylacetonate aluminum bis(ethyl-4,4,4-trifluoroacetoacetate)

monoacetylacetonate aluminum bis(ethyl-4,4,4-trifluoroacetoacetate)

Conditions
ConditionsYield
In toluene at 20℃; for 24h;100%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate
363-58-6

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

Conditions
ConditionsYield
With sulfuryl dichloride In dichloromethane at -5 - 20℃;99.3%
With chlorine In acetone95%
With chlorine at 0 - 30℃; Cooling with acetone-dry ice;95%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

recorcinol
108-46-3

recorcinol

7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
575-03-1

7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one

Conditions
ConditionsYield
With iodine In toluene at 80℃; Pechmann reaction;99%
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;97%
indium(III) chloride at 65℃; for 0.5h; von Pechmann reaction;96%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

Conditions
ConditionsYield
With formic acid; C18H24ClIrN3 In water at 80℃; for 8h; Schlenk technique; Inert atmosphere; chemoselective reaction;99%
With sodium tetrahydroborate In diethyl ether 1.) 0-5 deg C, 1 h, 2.) r.t., overnight;98%
With sodium tetrahydroborate In diethyl ether97%
7-ethyl-1H-indole
22867-74-9

7-ethyl-1H-indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-(7-ethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxybutanoate

ethyl 3-(7-ethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions
ConditionsYield
With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate In dichloromethane at 20℃; for 76h; Friedel-Crafts reaction; optical yield given as %ee; enantioselective reaction;99%
4-chlorobenzylamine
104-86-9

4-chlorobenzylamine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate
1384849-55-1

ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate

Conditions
ConditionsYield
Stage #1: 4-chlorobenzylamine With acetic acid In chloroform at 20℃; for 0.0833333h;
Stage #2: ethyl 4,4,4-trifluoroacetoacetate In chloroform for 5h; Reflux;
99%
6-methylbenzothiazol-2-ylamine
2536-91-6

6-methylbenzothiazol-2-ylamine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

8-methyl-2-(trifluoromethyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

8-methyl-2-(trifluoromethyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

Conditions
ConditionsYield
With indium(III) triflate In toluene at 100℃; for 16h; regioselective reaction;99%
4-hydrazinobenzene-1-sulfonamide hydrochloride
17852-52-7, 27918-19-0

4-hydrazinobenzene-1-sulfonamide hydrochloride

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
627094-59-1

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol at 24℃; Reflux; Inert atmosphere;99%
1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Pechmann Condensation; Glovebox; Inert atmosphere;99%
5-methylcyclohexan-1,3-dione
4341-24-6

5-methylcyclohexan-1,3-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7-methyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7-methyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
dimedone
126-81-8

dimedone

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7,7-dimethyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7,7-dimethyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
5-phenyl-cyclohexane-1,3-dione
493-72-1

5-phenyl-cyclohexane-1,3-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7-phenyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7-phenyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-aminosulfonylphenylhydrazine
4392-54-5

4-aminosulfonylphenylhydrazine

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
627094-59-1

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol for 12h; Reflux;99%
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate
571-55-1

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

Conditions
ConditionsYield
With acetic anhydride at 120 - 140℃; for 7h; Condensation;98%
With acetic anhydride at 135℃; for 18h;97.1%
In acetic anhydride for 8h; Reflux;95%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

5-(trifluoromethyl)-4-pyrazolin-3-one
76480-99-4

5-(trifluoromethyl)-4-pyrazolin-3-one

Conditions
ConditionsYield
With hydrazine hydrate In ethanol; water for 18h; Heating;98%
With water; hydrazine hydrate
With ethanol; hydrazine hydrate
5-amino-1,2-dihydropyrazol-3-one
28491-52-3

5-amino-1,2-dihydropyrazol-3-one

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-trifluoromethyl-6-hydroxy-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine

4-trifluoromethyl-6-hydroxy-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine

Conditions
ConditionsYield
With acetic acid for 2h; Heating;98%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

m-Hydroxyaniline
591-27-5

m-Hydroxyaniline

Coumarin 151
53518-15-3

Coumarin 151

Conditions
ConditionsYield
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;98%
With sulfuric acid In ethanol at 80℃;83%
With zinc(II) chloride In ethanol for 12h; Heating;69%
With zinc(II) chloride In ethanol Reflux;12%
With zinc(II) chloride In ethanol for 12h; Reflux;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-amino-4,4,4-trifluorocrotonate
141860-78-8

ethyl 3-amino-4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With ammonium acetate In cyclohexane; isopropyl alcohol98%
With ammonium acetate In ethanol; water88%
With ammonia
2,3;4,5-di-O-isopropylidene-β-D-fructopyranose
20880-92-6

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4,4,4-Trifluoro-3-oxo-butyric acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester

4,4,4-Trifluoro-3-oxo-butyric acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester

Conditions
ConditionsYield
With vermiculite In toluene for 48h; Heating;98%
((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
4099-85-8

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4,4,4-Trifluoro-3-oxo-butyric acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

4,4,4-Trifluoro-3-oxo-butyric acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With vermiculite In toluene for 48h; Heating;98%
indole
120-72-9

indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(indol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(indol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 1h; Friedel-Crafts hydroxyalkylation;98%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(2-methylindol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(2-methylindol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 0.75h; Friedel-Crafts hydroxyalkylation;98%
pyrrole
109-97-7

pyrrole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(pyrrol-2-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(pyrrol-2-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 0.5h; Friedel-Crafts hydroxyalkylation;98%
phenylhydrazine
100-63-0

phenylhydrazine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one
321-07-3

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one

Conditions
ConditionsYield
at 150 - 160℃; for 3h;98%
With acetic acid for 6h; Reflux;90%
With acetic acid Reflux;90%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate
85571-85-3

ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions
ConditionsYield
With α-D-glucose 6-phosphate; permeabilized cells of Bacillus pumilus Phe-C3; NADPH In various solvent(s) at 25℃; for 24h; pH=7.0;98%
With glucose dehydrogenase; pET28-bmgdh-cgcr; sodium carbonate In aq. phosphate buffer; toluene at 30℃; for 12h; pH=6.5; Enzymatic reaction; enantioselective reaction;92%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In dimethyl sulfoxide at 30℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;66%
phenylhydrazine
100-63-0

phenylhydrazine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole
96145-98-1

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole

Conditions
ConditionsYield
With acetic acid at 10 - 80℃; for 6.5h;98%
In ethanol at 24℃; for 12h; Reflux; Inert atmosphere;92%
In ethanol for 12h; Reflux;92%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

methylamine
74-89-5

methylamine

3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester
507448-65-9

3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester

Conditions
ConditionsYield
With acetic acid In ethanol; methyl cyclohexane at 80 - 90℃; under 760.051 Torr; for 3 - 4h; Product distribution / selectivity;98%
With acetic acid In methyl cyclohexane at 80 - 85℃; for 3 - 8h; Product distribution / selectivity;88.5%

372-31-6Upstream product

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