Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-

Base Information

• Chemical Name: Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-
• CAS No.: 126105-17-7
• Molecular Formula: C₁₄H₂₀ClN₃O₂
• Molecular Weight: 297.785
• DSSTox Substance ID: DTXSID80155082
• Nikkaji Number: J551.073B
• Wikidata: Q83022763
• Mol file: 126105-17-7.mol

Synonyms:Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-;126105-17-7;4-Amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxybenzamide;SCHEMBL9766463;DTXSID80155082;LS-25419;N-[2-(Cyclopropyl(methyl)amino)ethyl]-2-methoxy-4-amino-5-chlorobenzamide

Chemical Property of Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-

Chemical Property:

• Vapor Pressure: 5.83E-08mmHg at 25°C
• Boiling Point: 440.6°Cat760mmHg
• Flash Point: 220.2°C
• Density: 1.27g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 297.1244046
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCNC(=O)C1=CC(=C(C=C1OC)N)Cl)C2CC2

Technology Process of Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-

There total 8 articles about Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-N-cyclopropylethylenediamine (91907-31-2) → 2-methoxy-4-amino-5-chloro-N-(2-(methylcyclopropylamino)ethyl)-benzamide (126105-17-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / 0.5 h / 50 - 70 °C

2: 100 percent / H₂, HCl / 5percent Pd/C / ethanol / 2 h / Ambient temperature

3: 91 percent / potassium carbonate / dimethylformamide / 0.25 h / 80 °C

4: 88 percent / 15percent aq. HCl / 2 h / Heating

5: tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(93)90129-3

Reference yield:

N-acetyl-N'benzyl-N'-cyclopropylethylenediamine (126105-21-3) → 2-methoxy-4-amino-5-chloro-N-(2-(methylcyclopropylamino)ethyl)-benzamide (126105-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂, HCl / 5percent Pd/C / ethanol / 2 h / Ambient temperature

2: 91 percent / potassium carbonate / dimethylformamide / 0.25 h / 80 °C

3: 88 percent / 15percent aq. HCl / 2 h / Heating

4: tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(93)90129-3

Reference yield:

N-acetyl-N'-cyclopropyl-N'-methylethylenediamine (126105-23-5) → 2-methoxy-4-amino-5-chloro-N-(2-(methylcyclopropylamino)ethyl)-benzamide (126105-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 15percent aq. HCl / 2 h / Heating

2: tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1016/0223-5234(93)90129-3

upstream raw materials:

(4-Amino-5-chloro-2-methoxy-phenyl)-imidazol-1-yl-methanone

N-cyclopropyl-N-methylethylenediamine

4-amino-5-chloro-2-methoxybenzoic acid

N-benzyl-N-cyclopropylethylenediamine