6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde

Base Information

Chemical Name:6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde
CAS No.:114475-84-2
Molecular Formula:C₁₈H₁₆O₆
Molecular Weight:328.321
Hs Code.:
DSSTox Substance ID:DTXSID40553005
Wikidata:Q82433468
Mol file:114475-84-2.mol

Synonyms:114475-84-2;DTXSID40553005;6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde

Suppliers and Price of 6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:328.09468823
Heavy Atom Count:24
Complexity:453

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)CC(=O)C2=CC3=C(C=C2)OCO3)C=O)OC

Technology Process of 6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde

There total 6 articles about 6-[2-(2H-1,3-Benzodioxol-5-yl)-2-oxoethyl]-2,3-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106367-88-8
6-(chloromethyl)-2,3-dimethoxybenzoic acid methyl ester

: 114475-84-2
2,3-dimethoxy-6-(3,4-methylenedioxyphenacyl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / zinc chloride, naphthalene, lithium, 10percent hydrochloric acid / 1,2-dimethoxy-ethane / 1 h

2: 97 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Heating

3: 1.) oxalyl dichloride; 2.) triethylamine / 1.) dichloromethane, DMSO, -60 deg C, 15 min; 2.) dichloromethane, 5 min

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; naphthalene; lithium; triethylamine; zinc(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 56579-86-3
2-(3,4-methylenedioxyphenyl)-1,3-dithiane

: 114475-84-2
2,3-dimethoxy-6-(3,4-methylenedioxyphenacyl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h; 2.) THF, -78 deg C to r.t., 3 h

2: 85 percent / glyoxylic acid hydrate, conc. hydrochloric acid / acetic acid / 1.) steam-bath, 20 min; 2.) r.t., 18 h

3: LiAlH₄

4: 1.) oxalyl dichloride; 2.) triethylamine / 1.) dichloromethane, DMSO, -60 deg C, 15 min; 2.) dichloromethane, 5 min

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; triethylamine; Glyoxilic acid; In acetic acid;

Reference yield:

: 114475-89-7
3,4-dihydro-7,8-dimethoxy-3-(3,4-methylenedioxyphenyl)isocoumarin

: 114475-84-2
2,3-dimethoxy-6-(3,4-methylenedioxyphenacyl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Heating

2: 1.) oxalyl dichloride; 2.) triethylamine / 1.) dichloromethane, DMSO, -60 deg C, 15 min; 2.) dichloromethane, 5 min

With lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; In tetrahydrofuran;