Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

Base Information

Chemical Name:Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
CAS No.:114610-02-5
Molecular Formula:C19H17F2N5O3
Molecular Weight:401.372
Hs Code.:
Mol file:114610-02-5.mol

Synonyms:

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Chemical Property of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

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Technology Process of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

There total 11 articles about Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 114610-22-9
6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester

: 114610-02-5
6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; at 70 ℃; for 0.25h;
DOI:10.1248/cpb.38.3359

Reference yield: 35.0%

: 109-01-3
1-methyl-piperazine

: 134202-67-8
1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

: 114610-02-5
6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid

Guidance literature:: In N,N-dimethyl-formamide; at 120 - 130 ℃; for 3h;
DOI:10.1248/cpb.38.3359

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 114610-02-5
6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaNO₂, 20percent HCl, 2) NaOAc / 1) H₂O, 2) EtOH, CHCl₃

2: 95 percent / potassium tert-butoxide / dioxane / 1 h / Ambient temperature

3: 83 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

4: 92 percent / aq. NaOH / 0.25 h / 70 °C

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; sodium acetate; triethylamine; sodium nitrite; In 1,4-dioxane; acetonitrile;
DOI:10.1248/cpb.38.3359