Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- , ethyl ester

Base Information

• Chemical Name: Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- , ethyl ester
• CAS No.: 114610-22-9
• Molecular Formula: C21H21F2N5O3
• Molecular Weight: 429.426
• Mol file: 114610-22-9.mol

Synonyms:

Chemical Property of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- , ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- , ethyl ester

There total 9 articles about Pyrido[2,3-c]pyridazine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- , ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-methyl-piperazine (109-01-3) + ethyl 7-chloro-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate (125558-70-5) → 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester (114610-22-9)

Guidance literature:

With triethylamine; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1248/cpb.38.3359

Reference yield: 81.0%

1-methyl-piperazine (109-01-3) + ethyl 1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylsulfonyl)pyrido<2,3-c>pyridazine-3-carboxylate (134202-66-7) → 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester (114610-22-9)

Guidance literature:

With triethylamine; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1248/cpb.38.3359

Reference yield: 49.0%

1-methyl-piperazine (109-01-3) + ethyl 7-(p-tolylthio)-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate (134202-65-6) → 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester (114610-22-9)

Guidance literature:

In acetonitrile; for 5h; Heating;

DOI:10.1248/cpb.38.3359

upstream raw materials:

1-methyl-piperazine

ethyl 7-chloro-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate

ethyl 7-(p-tolylthio)-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate

ethyl 1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylsulfonyl)pyrido<2,3-c>pyridazine-3-carboxylate

Downstream raw materials:

6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid

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