[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-(1-bromobutyl)-4-chloro-5-formyl-1H-imidazol-1-yl]methyl]-, methyl ester

Base Information

Chemical Name:[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-(1-bromobutyl)-4-chloro-5-formyl-1H-imidazol-1-yl]methyl]-, methyl ester
CAS No.:114772-67-7
Molecular Formula:C23H22BrClN2O3
Molecular Weight:489.796
Hs Code.:
Mol file:114772-67-7.mol

Synonyms:

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Chemical Property of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-(1-bromobutyl)-4-chloro-5-formyl-1H-imidazol-1-yl]methyl]-, methyl ester

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Technology Process of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-(1-bromobutyl)-4-chloro-5-formyl-1H-imidazol-1-yl]methyl]-, methyl ester

There total 12 articles about [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-(1-bromobutyl)-4-chloro-5-formyl-1H-imidazol-1-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 114772-66-6
2-butyl-4-chloro-5-formyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole

: 114772-67-7
1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane; for 0.5h; Irradiation;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114772-67-7
1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 56 percent / manganese dioxide / CH₂Cl₂ / 40 h / 25 °C

7: 40 percent / N-bromosuccinimide / CCl₄ / 0.5 h / Irradiation

With hydrogenchloride; manganese(IV) oxide; N-Bromosuccinimide; sodium methylate; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114772-67-7
1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 56 percent / manganese dioxide / CH₂Cl₂ / 40 h / 25 °C

5: 40 percent / N-bromosuccinimide / CCl₄ / 0.5 h / Irradiation

With manganese(IV) oxide; N-Bromosuccinimide; sodium methylate; copper; dibenzoyl peroxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00112a031