2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Base Information

• Chemical Name: 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole
• CAS No.: 114773-40-9
• Molecular Formula: C₂₉H₃₇ClN₂O₃Si
• Molecular Weight: 525.163
• Mol file: 114773-40-9.mol

Synonyms:2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Chemical Property of 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

There total 3 articles about 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-imidazole (288-32-4) + 1-[(2'-Carbomethoxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloro-5-hydroxymethylimidazole (114772-69-9) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole (114773-40-9)

Guidance literature:

In hexane; water; N,N-dimethyl-formamide;

Reference yield:

2-(1-trans-butenyl)-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxaldehyde (114772-68-8) → 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole (114773-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; sodium borohydrid / methanol; water

2: hexane; water; N,N-dimethyl-formamide

With sodium hydroxide; sodium borohydrid; In methanol; hexane; water; N,N-dimethyl-formamide;

Reference yield:

1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde (114772-67-7) → 2-(But-1-en-1-yl)-5-t-butyldimethylsilyloxymethyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole (114773-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: sodium hydroxide; sodium borohydrid / methanol; water

3: hexane; water; N,N-dimethyl-formamide

With sodium hydroxide; sodium borohydrid; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide;

upstream raw materials:

1H-imidazole

1-[(2'-Carbomethoxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloro-5-hydroxymethylimidazole

tert-butyldimethylsilyl chloride

2-(1-trans-butenyl)-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxaldehyde