[1,1'-Biphenyl]-2-carboxamide, 4'-[[2-butyl-4-chloro-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol- 1-yl]methyl]-N-methoxy-

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-carboxamide, 4'-[[2-butyl-4-chloro-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol- 1-yl]methyl]-N-methoxy-
• CAS No.: 114772-85-9
• Molecular Formula: C27H34ClN3O5
• Molecular Weight: 516.037
• Mol file: 114772-85-9.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-carboxamide, 4'-[[2-butyl-4-chloro-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol- 1-yl]methyl]-N-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-Biphenyl]-2-carboxamide, 4'-[[2-butyl-4-chloro-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol- 1-yl]methyl]-N-methoxy-

There total 12 articles about [1,1'-Biphenyl]-2-carboxamide, 4'-[[2-butyl-4-chloro-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol- 1-yl]methyl]-N-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → 2-butyl-4-chloro-1-<<2'-<(methoxyamino)carbonyl>biphenyl-4-yl>methyl>-5-<<(2-methoxyethoxy)methoxy>methyl>imidazole (114772-85-9)

Guidance literature:

Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

7: 80 percent / potassium methanethiolate / dimethylformamide / 4 h / 125 °C

8: 1.) oxalyl chloride, N-methylmorpholine / 1.) chloroform, DMF, -20 deg C, 0.35 h, 2.) a) 25 deg C, 4 h, b) reflux, 40 h

With 4-methyl-morpholine; hydrogenchloride; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium methylate; potassium methanethiolate; acetyl chloride; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a031

Reference yield:

4-tolyl iodide (624-31-7) → 2-butyl-4-chloro-1-<<2'-<(methoxyamino)carbonyl>biphenyl-4-yl>methyl>-5-<<(2-methoxyethoxy)methoxy>methyl>imidazole (114772-85-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

5: 80 percent / potassium methanethiolate / dimethylformamide / 4 h / 125 °C

6: 1.) oxalyl chloride, N-methylmorpholine / 1.) chloroform, DMF, -20 deg C, 0.35 h, 2.) a) 25 deg C, 4 h, b) reflux, 40 h

With 4-methyl-morpholine; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium methylate; potassium methanethiolate; copper; tert-butyl alcohol; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a031

Reference yield:

o-tolylbenzoic acid (7148-03-0) → 2-butyl-4-chloro-1-<<2'-<(methoxyamino)carbonyl>biphenyl-4-yl>methyl>-5-<<(2-methoxyethoxy)methoxy>methyl>imidazole (114772-85-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

5: 80 percent / potassium methanethiolate / dimethylformamide / 4 h / 125 °C

6: 1.) oxalyl chloride, N-methylmorpholine / 1.) chloroform, DMF, -20 deg C, 0.35 h, 2.) a) 25 deg C, 4 h, b) reflux, 40 h

With 4-methyl-morpholine; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium methylate; potassium methanethiolate; acetyl chloride; tert-butyl alcohol; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a031

upstream raw materials:

O-Methylhydroxylamin

2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloro-5-<<(2-methoxyethoxy)methoxy>methyl>imidazole

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4-tolyl iodide

Downstream raw materials:

2-butyl-4-chloro-5-hydroxymethyl-1-<<2'-<(methoxyamino)carbonyl>biphenyl-4-yl>methyl>imidazole