O-Methylhydroxylamine

Base Information

• Chemical Name: O-Methylhydroxylamine
• CAS No.: 67-62-9
• Molecular Formula: CH5 N O
• Molecular Weight: 47.0568
• European Community (EC) Number: 200-660-1
• UNII: 9TZH4WY30J
• DSSTox Substance ID: DTXSID8043862
• Nikkaji Number: J349B
• Wikipedia: Methoxyamine
• Wikidata: Q18344129
• NCI Thesaurus Code: C78084
• ChEMBL ID: CHEMBL1213633
• Mol file: 67-62-9.mol

Synonyms:methoxyamine;methoxyamine hydrochloride;methoxylamine;O-methylhydroxylamine

Chemical Property of O-Methylhydroxylamine

Chemical Property:

• Appearance/Colour: white to yellowish crystals
• Vapor Pressure: 298mmHg at 25°C
• Melting Point: 149 - 152 ºC
• Refractive Index: 1.4164 (estimate)
• Boiling Point: 49.5 °C at 760 mmHg
• PKA: 12.5(at 25℃)
• PSA: 35.25000
• Density: 0.854 g/cm³
• LogP: 0.20680
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 47.037113783
• Heavy Atom Count: 3
• Complexity: 4.8

Purity/Quality:

99%, ^*data from raw suppliers

Dapansutrile ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Toxic by ingestion, strong skin irritant.
• Hazard Codes: Toxic by ingestion, strong skin irritant.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydroxylamines
• Canonical SMILES: CON
• Recent ClinicalTrials: Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer
• Uses: Analytical reagent, mainly for ketones and aldehydes.

Technology Process of O-Methylhydroxylamine

There total 43 articles about O-Methylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

O-methyl hydroxylamine disulfonic acid sodium salt → O-Methylhydroxylamin (67-62-9)

Guidance literature:

With sulfuric acid; In water; at 90 ℃; for 24h;

Reference yield: 72.0%

N-methoxylamine hydrochloride (593-56-6) → O-Methylhydroxylamin (67-62-9)

Guidance literature:

With sodium hydroxide; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.inorgchem.8b02947

Reference yield:

1-(4-Methoxy-phenyl)-ethanone O-methyl-oxime (72278-08-1,80965-21-5,80965-23-7) → O-Methylhydroxylamin (67-62-9) + 1-(4-methoxyphenyl)ethanone (100-06-1)

Guidance literature:

With water; In acetonitrile; at 4 ℃; Quantum yield; Irradiation; pH = 8.0;

DOI:10.1021/jo00385a030

upstream raw materials:

N-methoxyphthalimide

1,3-diphenyl-3-methoxyaminopropan-1-one

sodium methylate

methanol

Downstream raw materials:

N-butylamine

1-methoxy-4-(4-methoxy-phenyl)-3H-pyridine-2,6-dione

3-nitro-benzaldehyde-(O-methyl-seqcis-oxime )

(E)-3-nitrobenzaldehyde O-methyloxime

Refernces

• 1、 Kawai, Jun,Tsunashima, Shigeru,Sato, Shin. "The Reactions of Singlet NH Radicals with Methyl and Ethyl Alcohols in the Liquid Phase". . p. 3312 - 3316. Retrieved 1982.
• 2、 Clemens, Andrea,Kreher, Richard P.,Preut, Johannes. "Studies on the Chemistry of Isoindoles and Isoindolenines, XXXX [1,2] 3-Hydroximino-1-alkyl(aryl)-isoindolines and 3-Hydroxylamino-1-alkyl(aryl)-1H-isoindoles - Model Compounds for Investigations of Structure and Reactivity -". . p. 1791 - 1814. Retrieved 1996.
• 3、 Han, Gun Su,Domaille, Dylan W.. "Tuning the exchange dynamics of boronic acid hydrazones and oximes with pH and redox control". supporting information. p. 4986 - 4991. Retrieved 2021/06/16.
• 4、 -. "Methoxylamine preparation method and methoxylamine hydrochloride preparation method". Paragraph 0056-0061; 0077-0079. . Retrieved 2021/01/04.