6-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 6-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 114858-39-8
• Molecular Formula: C13H12ClNO2
• Molecular Weight: 249.69300
• Hs Code.: 2933499090
• Mol file: 114858-39-8.mol

Synonyms:ethyl 6-Chloro-2-methylquinoline-3carboxylate;3-Quinolinecarboxylic acid,6-chloro-2-methyl-,ethyl ester;6-Chloro-2-methylquinoline-3-carboxylic acid ethyl ester;

Chemical Property of 6-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 8.64E-05mmHg at 25°C
• Boiling Point: 340.4oC at 760 mmHg
• Flash Point: 159.7oC
• PSA: 39.19000
• Density: 1.252g/cm3
• LogP: 3.37330

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-2-methylquinoline-3-carboxylic acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 6-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 15 articles about 6-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-5-chlorobenzaldehyde (20028-53-9) + ethyl acetoacetate (141-97-9) → ethyl 6-chloro-2-methylquinoline-3-carboxylate (114858-39-8)

Guidance literature:

With charcoal MgO; In neat (no solvent); at 49.84 ℃; for 0.25h; Temperature; regioselective reaction; Green chemistry;

DOI:10.1002/cctc.201402602

Reference yield: 89.0%

C8H5ClN4O2 + ethyl acetoacetate (141-97-9) → ethyl 6-chloro-2-methylquinoline-3-carboxylate (114858-39-8)

Guidance literature:

C₈H₅ClN₄O₂; ethyl acetoacetate; With triethylamine; L-proline; In dichloromethane; at 20 ℃; Inert atmosphere;

With triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2013.07.050

Reference yield: 72.0%

ethyl 3-((4-chlorophenyl)amino)but-2-enoate (41014-75-9) → ethyl 6-chloro-2-methylquinoline-3-carboxylate (114858-39-8)

Guidance literature:

With trichlorophosphate; In DMF (N,N-dimethyl-formamide); 1,2-dichloro-ethane; at 20 ℃; for 7.16667h; Heating / reflux;

upstream raw materials:

ethyl acetoacetate

4-chloro-aniline

N,N-dimethyl-formamide

ethyl 3-((4-chlorophenyl)amino)but-2-enoate

Refernces

• 1、 Godino-Ojer, Marina,Lpez-Peinado, Antonio J.,Martn-Aranda, Rosa M.,Przepirski, Jacek,Prez-Mayoral, Elena,Soriano, Elena. "Eco-friendly catalytic systems based on carbon-supported magnesium oxide materials for the friedl?nder condensation". . p. 3440 - 3447. Retrieved 2014.
• 2、 Li, Jianjun,Fu, Yiwei,Qin, Cong,Yu, Yang,Li, Hao,Wang, Wei. "Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid". . p. 6474 - 6477. Retrieved 2017.
• 3、 Zhu, Zhengbo,Seidel, Daniel. "Acetic Acid Promoted Redox Annulations with Dual C-H Functionalization". supporting information. p. 2841 - 2844. Retrieved 2017/06/07.