2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-

Base Information

Chemical Name:2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-
CAS No.:115363-87-6
Molecular Formula:C13H16BrNO2
Molecular Weight:298.18
Hs Code.:
DSSTox Substance ID:DTXSID70476258
Mol file:115363-87-6.mol

Synonyms:2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-;115363-87-6;DTXSID70476258

Suppliers and Price of 2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:297.03644
Heavy Atom Count:17
Complexity:272

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1CCC(=O)N1CC2=CC=CC=C2Br

Technology Process of 2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy-

There total 3 articles about 2-Pyrrolidinone, 1-[(2-bromophenyl)methyl]-5-ethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 115363-87-6
N-(o-bromobenzyl)-5-ethoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KOH / 1.) DMF, 0 deg C, 1.75 h, 2.) RT, 5 h

2: 1.) NaBH₄, 2.) 2N HCl / 1.) -20 deg C to -10 deg C, 4.5 h, 2.) pH=3, 5 deg C, 1 h

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate;
DOI:10.1021/jo00253a028

Reference yield:

: 115363-86-5
1-(2-bromobenzyl)pyrrolidine-2,5-dione

: 115383-45-4
N-(o-bromobenzyl)-5-hydroxy-2-pyrrolidinone

: 115363-87-6
N-(o-bromobenzyl)-5-ethoxy-2-pyrrolidinone

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; Title compound not separated from byproducts; 1.) ethanol, -20 deg C to -10 deg C, 4.5 h, 2.) pH=3, 5 deg C, 1 h;
DOI:10.1021/jo00253a028

Reference yield:

: 64-17-5
ethanol

: 115363-86-5
1-(2-bromobenzyl)pyrrolidine-2,5-dione

: 115383-45-4
N-(o-bromobenzyl)-5-hydroxy-2-pyrrolidinone

: 115363-87-6
N-(o-bromobenzyl)-5-ethoxy-2-pyrrolidinone

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; Title compound not separated from byproducts; 1.) -20 deg C to -10 deg C, 4.5 h, 2.) pH=3, 5 deg C, 1 h;
DOI:10.1021/jo00253a028