3-Buten-2-one, 3-(1,3,2-dioxaphosphorinan-2-yl)-4-(2-nitrophenyl)-, P-oxide

Base Information

• Chemical Name: 3-Buten-2-one, 3-(1,3,2-dioxaphosphorinan-2-yl)-4-(2-nitrophenyl)-, P-oxide
• CAS No.: 115550-22-6
• Molecular Formula: C13H14NO6P
• Molecular Weight: 311.22700
• Mol file: 115550-22-6.mol

Synonyms:2-<1-(2-nitrobenzylidene)acetonyl>-2-oxo-1,3,2-dioxaphosphorinane;1-[1-(2-nitrobenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane;(E)-4-(2-Nitro-phenyl)-3-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-but-3-en-2-one;

Chemical Property of 3-Buten-2-one, 3-(1,3,2-dioxaphosphorinan-2-yl)-4-(2-nitrophenyl)-, P-oxide

Chemical Property:

• PSA: 108.23000
• LogP: 3.67790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Buten-2-one, 3-(1,3,2-dioxaphosphorinan-2-yl)-4-(2-nitrophenyl)-, P-oxide

There total 8 articles about 3-Buten-2-one, 3-(1,3,2-dioxaphosphorinan-2-yl)-4-(2-nitrophenyl)-, P-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

acetic anhydride (108-24-7) + Isobutyl-[1-(2-nitro-phenyl)-meth-(E)-ylidene]-amine (27895-79-0) + 2-acetonyl-2-oxo-1,3,2-dioxaphosphorinane (115579-08-3) → N-isobutylacetamide (1540-94-9) + 1-<1-(2-nitrobenzylidene)acetonyl>-2-oxo-1,3,2-dioxaphosphorinane (115550-22-6)

Guidance literature:

In benzene; for 4h; Heating;

DOI:10.1248/cpb.36.1139

Reference yield: 68.0%

Isobutyl-[1-(2-nitro-phenyl)-meth-(E)-ylidene]-amine (27895-79-0) + 2-acetonyl-2-oxo-1,3,2-dioxaphosphorinane (115579-08-3) → N-isobutylacetamide (1540-94-9) + 1-<1-(2-nitrobenzylidene)acetonyl>-2-oxo-1,3,2-dioxaphosphorinane (115550-22-6)

Guidance literature:

With acetic anhydride; In benzene; for 4h; Heating;

DOI:10.1248/cpb.36.1139

Reference yield:

2-allenyl-2-oxo-1,3,2-dioxaphosphorinane (55665-69-5) → 1-<1-(2-nitrobenzylidene)acetonyl>-2-oxo-1,3,2-dioxaphosphorinane (115550-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 1.) r. t., 16 h, 2.) 60 deg C, 1 h

2: oxalic acid dihydrate / ethyl acetate / 18 h / Ambient temperature

3: 68 percent / benzene / 4 h / Heating

With oxalic acid; In ethyl acetate; acetonitrile; benzene;

DOI:10.1248/cpb.36.1139

upstream raw materials:

acetic anhydride

Isobutyl-[1-(2-nitro-phenyl)-meth-(E)-ylidene]-amine

2-acetonyl-2-oxo-1,3,2-dioxaphosphorinane

C₁₀H₂₀NO₃P

Downstream raw materials:

2,6-Dimethyl-4-(2-nitro-phenyl)-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-1-propyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

2,6-Dimethyl-4-(2-nitro-phenyl)-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-1,4-dihydro-pyridine-3-carboxylic acid tert-butyl ester

methyl 1-ethyl-2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate

Isopropyl 2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate