1,4-Benzenedicarboxylic acid, 2,5-bis(acetylamino)-, dimethyl ester

Base Information

• Chemical Name: 1,4-Benzenedicarboxylic acid, 2,5-bis(acetylamino)-, dimethyl ester
• CAS No.: 115705-52-7
• Molecular Formula: C14H16N2O6
• Molecular Weight: 308.291
• Mol file: 115705-52-7.mol

Synonyms:

Chemical Property of 1,4-Benzenedicarboxylic acid, 2,5-bis(acetylamino)-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-Benzenedicarboxylic acid, 2,5-bis(acetylamino)-, dimethyl ester

There total 8 articles about 1,4-Benzenedicarboxylic acid, 2,5-bis(acetylamino)-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitroterephthalic acid (610-29-7) → 2,5-diacetamidoterephthalic acid dimethyl ester (115705-52-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 100 percent / KOH, H₂ / 5percent Pd/C / H₂O / 12 h / 2585.7 Torr

2: 53 percent / 150 °C

3: HNO₃, H₂SO₄ / 5 - 10 °C

4: H₂O / 0 °C

5: KOH, H₂ / 5percent Pd/C / H₂O / 2 h / 2585.7 Torr

6: H₂O / 3 h

7: 87 percent / acetic anhydride / acetic acid / 2 h / Heating

8: sodium methoxide / 1 h / Heating

With potassium hydroxide; sulfuric acid; water; hydrogen; nitric acid; sodium methylate; acetic anhydride; palladium on activated charcoal; In water; acetic acid;

DOI:10.1021/jo00253a010

Reference yield:

2-formamidoterephthalic acid (115705-49-2) → 2,5-diacetamidoterephthalic acid dimethyl ester (115705-52-7)

Guidance literature:

Multi-step reaction with 6 steps

1: HNO₃, H₂SO₄ / 5 - 10 °C

2: H₂O / 0 °C

3: KOH, H₂ / 5percent Pd/C / H₂O / 2 h / 2585.7 Torr

4: H₂O / 3 h

5: 87 percent / acetic anhydride / acetic acid / 2 h / Heating

6: sodium methoxide / 1 h / Heating

With potassium hydroxide; sulfuric acid; water; hydrogen; nitric acid; sodium methylate; acetic anhydride; palladium on activated charcoal; In water; acetic acid;

DOI:10.1021/jo00253a010

Reference yield:

2-Formylamino-5-nitro-terephthalic acid → 2,5-diacetamidoterephthalic acid dimethyl ester (115705-52-7)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂O / 0 °C

2: KOH, H₂ / 5percent Pd/C / H₂O / 2 h / 2585.7 Torr

3: H₂O / 3 h

4: 87 percent / acetic anhydride / acetic acid / 2 h / Heating

5: sodium methoxide / 1 h / Heating

With potassium hydroxide; water; hydrogen; sodium methylate; acetic anhydride; palladium on activated charcoal; In water; acetic acid;

DOI:10.1021/jo00253a010

upstream raw materials:

2-acetylamino-5-amino-terephthalic acid dimethyl ester

acetic anhydride

methanol

2,7-dimethyl-benzo[1,2-d;4,5-d']bis[1,3]oxazine-4,9-dione

Downstream raw materials:

2,5-diacetamido-3-nitroterephthalic acid dimethyl ester