2-chloro-1-methyl-5-nitro-imidazole

Base Information

• Chemical Name: 2-chloro-1-methyl-5-nitro-imidazole
• CAS No.: 86072-07-3
• Molecular Formula: C4H4 Cl N3 O2
• Molecular Weight: 161.548
• Hs Code.: 2933290090
• Mol file: 86072-07-3.mol

Synonyms:P18

Chemical Property of 2-chloro-1-methyl-5-nitro-imidazole

Chemical Property:

• Vapor Pressure: 0.000132mmHg at 25°C
• Boiling Point: 333.9°C at 760 mmHg
• Flash Point: 155.7°C
• PSA: 63.64000
• Density: 1.65g/cm³
• LogP: 1.50490

Purity/Quality:

2-Chloro-1-methyl-5-nitro-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-1-methyl-5-nitro-imidazole

There total 2 articles about 2-chloro-1-methyl-5-nitro-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-chloro-4-nitro-1H-imidazole (57531-37-0) → 2-chloro-1-methyl-5-nitroimidazole (86072-07-3) + 2-chloro-1-methyl-4-nitro-1H-imidazole (63634-21-9)

Guidance literature:

In diethyl ether; Ambient temperature;

Reference yield:

2-chloro-4-nitro-1H-imidazole (57531-37-0) + dimethyl sulfate (77-78-1) → 2-chloro-1-methyl-5-nitroimidazole (86072-07-3) + 2-chloro-1-methyl-4-nitro-1H-imidazole (63634-21-9)

Guidance literature:

With benzyltrimethylammonium chloride; In toluene; at 120 - 125 ℃; for 8h;

Reference yield:

2-chloro-1-methyl-5-nitroimidazole (86072-07-3) + 1-(methylsulphonyl)-2-oxo-2,3,4,5-tetrahydroimidazole (41730-79-4) → 1 (1 methyl 5 nitroimidazol 2 yl) 3 (methylsulfonyl)imidazolidin 2 one (56302-13-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; 1.) 30 min, room temperature, 2.) a) 1 h, room temperture, b) 3 h, 55 deg C, c) room temperature;

upstream raw materials:

diazomethane

2-chloro-4-nitro-1H-imidazole

dimethyl sulfate

Downstream raw materials:

1 (1 methyl 5 nitroimidazol 2 yl) 3 (methylsulfonyl)imidazolidin 2 one