Benzene, 1-methoxy-4-(4-phenyl-3-buten-1-ynyl)-, (E)-

Base Information

• Chemical Name: Benzene, 1-methoxy-4-(4-phenyl-3-buten-1-ynyl)-, (E)-
• CAS No.: 116156-19-5
• Molecular Formula: C17H14O
• Molecular Weight: 234.298
• Mol file: 116156-19-5.mol

Synonyms:

Chemical Property of Benzene, 1-methoxy-4-(4-phenyl-3-buten-1-ynyl)-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-methoxy-4-(4-phenyl-3-buten-1-ynyl)-, (E)-

There total 12 articles about Benzene, 1-methoxy-4-(4-phenyl-3-buten-1-ynyl)-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

bromostyrene (103-64-0,1340-14-3) + 4-methoxyphenylacetylen (768-60-5) → (E)-1-methoxy-4-(4-phenylbutyl-3-en-1-yn-1-yl)benzene (116156-19-5)

Guidance literature:

With copper(l) iodide; tetrabutylammonium acetate; potassium carbonate; triphenylphosphine; In water; dimethyl sulfoxide; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2013.06.063

Reference yield: 89.0%

[(E)-2-bromoethenyl]benzene (588-72-7,1340-14-3) + 4-methoxyphenylacetylen (768-60-5) → (E)-1-methoxy-4-(4-phenylbutyl-3-en-1-yn-1-yl)benzene (116156-19-5)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200900954

Reference yield: 80.0%

bromostyrene (103-64-0,1340-14-3) + 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine (32117-52-5) → (E)-1-methoxy-4-(4-phenylbutyl-3-en-1-yn-1-yl)benzene (116156-19-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; oxygen; copper(l) chloride; In dimethyl sulfoxide; at 100 ℃; for 12h; under 760.051 Torr; regioselective reaction; Schlenk technique;

DOI:10.1002/anie.201405058

upstream raw materials:

[(E)-2-bromoethenyl]benzene

4-methoxyphenylacetylen

styrene

1-bromo-2-(4-methoxyphenyl)acetylene

Downstream raw materials:

(E)-1-(4-methoxyphenyl)-4-phenylbut-3-en-2-one

(Z)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4-dione

(3E)-1-(4-methoxyphenyl)-4-phenylbut-3-en-1-one

(E)-2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-4-phenyl-but-3-enal

Refernces

• 1、 Qiu, Shaozhong,Zhang, Caiyang,Qiu, Rui,Yin, Guodong,Huang, Jinkun. "One-Pot Domino Synthesis of Diarylalkynes/1,4-Diaryl-1,3-diynes by [9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene] (Xantphos)–Copper(I) Iodide–Palladium(II) Acetate-Catalyzed Double Sonogashira-Type Reaction". . p. 313 - 321. Retrieved 2018/01/15.
• 2、 Mokar, Bhanudas Dattatray,Liu, Rai-Shung. "Regioselective hydrations of 1-aryl-3-en-1-ynes using gold and platinum catalysts: Selective production of 2-en-1-ones and 3-en-1-ones". supporting information. p. 8966 - 8969. Retrieved 2014/08/05.