Diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate

Base Information

• Chemical Name: Diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate
• CAS No.: 40283-47-4
• Molecular Formula: C13H19N3O5S
• Molecular Weight: 329.3721
• NSC Number: 143666
• DSSTox Substance ID: DTXSID60301484
• Mol file: 40283-47-4.mol

Synonyms:40283-47-4;NSC143666;diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate;DTXSID60301484;NSC-143666

Chemical Property of Diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate

Chemical Property:

• Vapor Pressure: 1.09E-12mmHg at 25°C
• Boiling Point: 562.7°Cat760mmHg
• Flash Point: 294.1°C
• Density: 1.295g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 10
• Exact Mass: 329.10454189
• Heavy Atom Count: 22
• Complexity: 407

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)CCC(C(=O)OCC)NC(=O)C1=CN=C(S1)N

Technology Process of Diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate

There total 1 articles about Diethyl n-[(2-amino-1,3-thiazol-5-yl)carbonyl]glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminothiazole-5-carboxylic acid (40283-46-3) + glutamic acid diethyl ester hydrochloride (65710-34-1) → N-(2-amino-thiazole-5-carbonyl)-glutamic acid diethyl ester (40283-47-4)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide;

DOI:10.1021/jm00282a026

Reference yield:

N-(2-amino-thiazole-5-carbonyl)-glutamic acid diethyl ester (40283-47-4) + 2-acetylamino-4-hydroxy-6-formylpteridine (29769-49-1) → N-{2-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-thiazole-5-carbonyl}-glutamic acid (37746-94-4)

Guidance literature:

Multistep reaction; (i) 4-methyl-thiophenol, MeOCH₂CH₂OH, (ii) aq. NaOH, Et₂O;

DOI:10.1021/jm00282a026

upstream raw materials:

2-aminothiazole-5-carboxylic acid

glutamic acid diethyl ester hydrochloride

Downstream raw materials:

N-{2-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-thiazole-5-carbonyl}-glutamic acid