3-(tert-Butyldimethylsiloxy)butyric acid methyl ester

Base Information

Chemical Name:3-(tert-Butyldimethylsiloxy)butyric acid methyl ester
CAS No.:116414-91-6
Molecular Formula:C11H24O3Si
Molecular Weight:232.395
Hs Code.:
DSSTox Substance ID:DTXSID70547417
Nikkaji Number:J134.926K
Mol file:116414-91-6.mol

Synonyms:116414-91-6;3-(tert-Butyldimethylsiloxy)butyric acid methyl ester;methyl 3-[tert-butyl(dimethyl)silyl]oxybutanoate;Methyl 3-{[tert-butyl(dimethyl)silyl]oxy}butanoate;SCHEMBL5631757;DTXSID70547417;YMQKYTUCHSHLJI-UHFFFAOYSA-N;methyl (-)-3-t-butyldimethylsilyloxybutyrate

Suppliers and Price of 3-(tert-Butyldimethylsiloxy)butyric acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-(tert-Butyldimethylsiloxy)butyric acid methyl ester

Chemical Property:

PSA：35.53000
LogP:2.95980
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:232.14947116
Heavy Atom Count:15
Complexity:218

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC(=O)OC)O[Si](C)(C)C(C)(C)C

Technology Process of 3-(tert-Butyldimethylsiloxy)butyric acid methyl ester

There total 4 articles about 3-(tert-Butyldimethylsiloxy)butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

: 1487-49-6
3-hydroxybutyric acid methyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 116414-91-6
methyl-3-((tert-butyldimethylsilyl)oxy)butanoate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 30 ℃; for 3h; Inert atmosphere;

Reference yield:

: 81327-43-7
tert-butyldimethylsilyl ether-β-hydroxybutyric acid ethyl ester

: 116414-91-6
methyl-3-((tert-butyldimethylsilyl)oxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 87.1 percent / aq. NaOH / methanol / 20 h

2: diethyl ether / 0.25 h

With sodium hydroxide; In methanol; diethyl ether;
DOI:10.1021/jo00385a024

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 116414-91-6
methyl-3-((tert-butyldimethylsilyl)oxy)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide / 8 h

2: 87.1 percent / aq. NaOH / methanol / 20 h

3: diethyl ether / 0.25 h

With 1H-imidazole; sodium hydroxide; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a024