1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one

Base Information

• Chemical Name: 1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one
• CAS No.: 116545-09-6
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• DSSTox Substance ID: DTXSID50569117
• Wikidata: Q82456189
• Mol file: 116545-09-6.mol

Synonyms:116545-09-6;1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one;SCHEMBL10744367;DTXSID50569117

Chemical Property of 1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 208.08479225
• Heavy Atom Count: 15
• Complexity: 240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(=O)C[N+](=O)[O-]

Technology Process of 1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one

There total 8 articles about 1-[4-(Dimethylamino)phenyl]-2-nitroethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline (22568-06-5) → 4-N,N-dimethylamino-ω-nitroacetophenone (116545-09-6)

Guidance literature:

With tert.-butylhydroperoxide; n-butyllithium; In tetrahydrofuran; hexane; toluene; at -20 ℃; for 1.5h;

DOI:10.1055/s-1988-27523

Reference yield: 38.0%

N,N-dimethyl-aniline (121-69-7,77733-26-7) + 6-Nitro-2-phenyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one → 4-N,N-dimethylamino-ω-nitroacetophenone (116545-09-6) + 2-phenyl-6-nitro-7-(p-dimethylaminophenyl)-1,2,4-triazolo<1,5-a>pyrimidine

Guidance literature:

With trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF00532087

Reference yield: 35.0%

N,N-dimethyl-aniline (121-69-7,77733-26-7) + 5-Methyl-6-nitro-2-trifluoromethyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one → 4-N,N-dimethylamino-ω-nitroacetophenone (116545-09-6) + Dimethyl-[4-(5-methyl-6-nitro-2-trifluoromethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-phenyl]-amine

Guidance literature:

With trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF00532087

upstream raw materials:

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline

N,N-dimethyl-aniline

p-N,N-dimethylaminobenzoic acid

sodium nitromethane

Downstream raw materials:

2-diazo-1-[4-(dimethylamino)phenyl]-2-nitroethanone