22568-06-5

Upstream product

• 75-52-5 nitromethane 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 625-75-2 nitroacetic acid 

Downstream Products

• 52632-05-0 4-Dimethylaminophenethylamine 
• 28072-99-3 1-dimethylamino-4-(2-bromo-2-nitroethenyl)benzene 
• 95834-33-6 5-[1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 95834-29-0 5-[1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-6-hydroxyamino-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 128640-21-1 [1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-21-1 (R)-[(R)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-21-1 (R)-[(S)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-23-3 (R)-[(R)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester 
• 128640-23-3 (R)-[(S)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester 
• 128640-22-2 (R)-[(R)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid propyl ester 
• 128640-22-2 (R)-[(S)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid propyl ester 
• 75-52-5 nitromethane 
• 23630-92-4 1,1-dimethylamino-4-(2-nitroethyl)benzene 
• 116545-09-6 4-N,N-dimethylamino-ω-nitroacetophenone 

Relevant academic research and scientific papers

Nitromethane as a surrogate cyanating agent: 7-: N, N-dimethylamino-4-hydroxycoumarin-catalyzed, metal-free synthesis of α-iminonitriles

An efficient, metal/alkali-cyanide free approach for the synthesis of α-iminonitriles via kinetically controlled, base-mediated and 1,3-diketone-catalyzed reaction is reported. The preparation of target compounds was realized by condensation of substituted anilines and aldehydes in nitromethane as a surrogate cyanating agent and as a solvent. This strategy was further improved by replacing aldehydes and nitromethane with β-nitrostyrene and ethanol, respectively, rendering the methodology greener. The catalytic role played by 1,3-diketones such as 7-N,N-dimethylamino-4-hydroxycoumarin in this three-component reaction was investigated, and a plausible mechanism was proposed based on control experiments.

PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX) / histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel-Crafts Alkylation Using Aryl-Nitroolefins

A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy is composed of Zn(OTf)2-catalyzed Friedel-Crafts alkylation of N-benzylindolines with nitroolefins, and a series of diverse indolines was first obtained in up to 99% yield. This reaction provides a direct and practical route to a variety of the C5-alkylated indolines which were also utilized for accessing corresponding indoles. Indoline derivatives with free NH groups could be obtained through an N-deprotection reaction. Moreover, the primary alkyl nitro groups in both indolines and indoles are amenable to further synthetic elaborations, thereby broadening the diversity of the products.

One-Step, Effective, and Cascade Syntheses of Highly Functionalized Cyclopentenes with High Diastereoselectivity

Tetrabutylammonium fluoride works as an effective organocatalyst for the cycloaddition between phenacylmalononitriles and electron-deficient olefins (having substituent groups of NO2, CHO, and COR), providing a facile synthetic route to versatile multifunctionalized cyclopentenes having an allylic quaternary carbon center bearing both cyano and carboxamide groups with high yields and high diastereoselectivity. Preliminary studies reveal that these functionalized cyclopentenes are convenient precursors for making α-cyano-functionalized cyclopentadienone oximes.

A thiourea-functionalized metal-organic macrocycle for the catalysis of Michael additions and prominent size-selective effect

A discrete tetranuclear thiourea-based metal-organic macrocycle (MOM) with a large size was constructed by a well-designed organic ligand and nickel(ii) ions via self-assembly. Incorporating thiourea groups as hydrogen-bond donors into a metal-organic com

Tetraarylphosphonium inner-salts (TAPIS) as both Lewis base catalyst and phase tag

Tetraarylphosphonium inner-salts (TAPIS) have been designed, synthesized and verified as recyclable and reusable Lewis base catalysts. The resulted TAPIS catalyst has been successfully applied in Michael addition, cyanation and trifluoromethylation reactions.

An investigation on single crystal growth, structural, thermal and optical properties of a series of organic D-π-A push-pull materials

We present the large single crystal growth of a series of donor-π-acceptor (D-π-A) push-pull chromophores; 4-N,N-dimethylamino-β-nitrostyrene (1), 2-(4-(dimethylamino)benzylidene)malononitrile (2), ethyl 2-cyano-3-(4-(dimethylamino)phenyl)acrylate (3) and

Intramolecular interactions in nitroamines studied by 1H, 13C, 15N and 17O NMR spectral and quantum chemical methods

1H, 13C, 15N and 17O NMR chemical shifts are used for the characterization of the intramolecular interactions in several nitramines of the Me2N-G-NO2 type. The charge of lone electron pair

Hydantoin and thiohydantoin derivatives as antiviral drugs

The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.

HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS

The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.