1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene

Base Information

Chemical Name:1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene
CAS No.:116703-73-2
Molecular Formula:C9H8BrF3S
Molecular Weight:285.128
Hs Code.:
DSSTox Substance ID:DTXSID00557948
Mol file:116703-73-2.mol

Synonyms:116703-73-2;DTXSID00557948;1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene

Suppliers and Price of 1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:283.94822
Heavy Atom Count:14
Complexity:175

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=CC=C(C=C1)C(C(F)(F)F)Br

Technology Process of 1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene

There total 3 articles about 1-(1-Bromo-2,2,2-trifluoroethyl)-4-(methylsulfanyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122035-81-8
2,2,2-trifluoro-1-(4'-methylsulfanylphenyl)ethanol

: 116703-73-2
(4-(1-bromo-2,2,2-trifluoroethyl)phenyl)(methyl)sulfane

Guidance literature:: With phosphorus tribromide;
DOI:10.1021/ja00186a047

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 116703-73-2
(4-(1-bromo-2,2,2-trifluoroethyl)phenyl)(methyl)sulfane

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 3 h / 20 °C / Schlenk technique; Inert atmosphere

2.1: N-Bromosuccinimide; triphenyl phosphite / dichloromethane / 6 h / Reflux

With triphenyl phosphite; N-Bromosuccinimide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.0c03258

Reference yield:

: 122243-33-8
2,2,2-trifluoro-1-(4-methylsulfanyl-phenyl)-ethanone

: 116703-73-2
(4-(1-bromo-2,2,2-trifluoroethyl)phenyl)(methyl)sulfane

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄

2: PBr₃

With sodium tetrahydroborate; phosphorus tribromide;
DOI:10.1021/ja00186a047