5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid

Base Information

• Chemical Name: 5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid
• CAS No.: 118715-27-8
• Molecular Formula: C21H28O3Si
• Molecular Weight: 356.537
• DSSTox Substance ID: DTXSID10559039
• Nikkaji Number: J1.888.305H
• Wikidata: Q82441559
• Mol file: 118715-27-8.mol

Synonyms:118715-27-8;5-[(TERT-BUTYLDIPHENYLSILYL)OXY]PENTANOIC ACID;5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid;SCHEMBL6345426;DTXSID10559039;XRGGRUWGKRJRLX-UHFFFAOYSA-N;SY343640;F95188;5-(tert-Butyl-diphenyl-silanyloxy)pentanoic acid;5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid

Chemical Property of 5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 356.18077129
• Heavy Atom Count: 25
• Complexity: 386

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCCCCC(=O)O

Technology Process of 5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid

There total 13 articles about 5-{[tert-Butyl(diphenyl)silyl]oxy}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(tert-butyldiphenylsilyloxy)pentanal (131216-47-2) → 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid (118715-27-8)

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.1c01239

Reference yield: 82.0%

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl ester (179690-97-2) → 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid (118715-27-8)

Guidance literature:

With potassium hydroxide; In methanol; water; at 20 ℃; for 6h;

DOI:10.1021/ol0275116

Reference yield: 71.0%

(R)-5-[(tert-butyldiphenylsilyl)oxy]-N-{2-[(tert-butyldiphenylsilyl)oxy]-1-phenylethyl}-1-pentanamine → C48H54N2O4Si2 + 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid (118715-27-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.6b00513

upstream raw materials:

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl ester

5-(tert-butyldiphenylsilyloxy)pentanal

3-(4-(6-(tert-butyldiphenylsilyl-oxy)-2-hydroxyhexyl)phenoxy)-propyl 9,10-dioxo-9,10-dihydro-anthracene-2-carboxylate

tert-butylchlorodiphenylsilane

Downstream raw materials:

5-(tert-Butyl-diphenyl-silanyloxy)-pentanoic acid (3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

5-(tert-Butyl-diphenyl-silanyloxy)-pentanoic acid (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

5-(tert-Butyl-diphenyl-silanyloxy)-pentanoic acid (3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl ester

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid 3-methyl-but-2-enyl ester

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