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Technology Process of 1,10-Phenanthroline, 2,9-dimethyl-5-nitro-

1,10-Phenanthroline, 2,9-dimethyl-5-nitro-

Base Information
  • Chemical Name:1,10-Phenanthroline, 2,9-dimethyl-5-nitro-
  • CAS No.:118752-27-5
  • Molecular Formula:C14H11N3O2
  • Molecular Weight:253.26
  • Hs Code.:
  • Mol file:118752-27-5.mol
1,10-Phenanthroline, 2,9-dimethyl-5-nitro-

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The product has achieved commercial mass production*data from LookChem market partment
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Chemical Property of 1,10-Phenanthroline, 2,9-dimethyl-5-nitro-
Chemical Property:
Purity/Quality:

99.90% *data from raw suppliers

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Refernces

Synthesis of new OBAN's and further studies on positioning of the catalytic group.

10.1039/b403652b

The study focuses on the synthesis and evaluation of two new zinc ion-dependent oligonucleotide-based artificial nucleases (OBANs), OBAN 4 and OBAN 5. These OBANs are composed of 2'-O-methyl modified RNA oligomers conjugated to 5-amino-2,9-dimethylphenanthroline (neocuproine) via a urea linker. OBAN 4 features the catalytic group on a linker extending from the C-4 of an internal cytosine, while OBAN 5 has two neocuproine units attached via linkers from the C-5 position of uridine moieties. The synthesis involves conjugating the catalytic group to the amino linkers of the modified oligonucleotides by converting 5-amino-2,9-dimethylphenanthroline to phenylcarbamate and reacting it with oligonucleotides carrying primary aliphatic amines in aqueous buffer. Both OBAN systems are found to cleave RNA in bulged-out regions from non-complementary parts of the target sequences in the presence of Zn(II) ions, with differences in efficiency compared to previous systems discussed. The study also explores the influence of linker and linker position, as well as target RNA structure, on cleavage efficiency, providing insights into the development of more efficient OBAN systems for potential applications in life science and biotechnology.

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