Technology Process of Diethyl [2-(3-chlorophenyl)ethyl]propanedioate
There total 1 articles about Diethyl [2-(3-chlorophenyl)ethyl]propanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 1h;
Inert atmosphere;
2-(3-chlorophenyl)ethyl bromide;
In
tetrahydrofuran; mineral oil;
for 23h;
Reflux;
Inert atmosphere;
DOI:10.1021/acs.joc.8b00475
- Guidance literature:
-
diethyl 2-(3-chlorophenethyl)malonate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 1h;
Inert atmosphere;
1-iodo-3-chloro-propane;
In
tetrahydrofuran; mineral oil;
for 22h;
Inert atmosphere;
DOI:10.1021/acs.joc.8b00475
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere
1.2: 22 h / Inert atmosphere
2.1: sodium azide / N,N-dimethyl-formamide / 48 h / 50 °C
3.1: potassium hydroxide / methanol; water / 16 h / 70 °C
4.1: acetic acid / 12 h / 160 °C
With
sodium azide; sodium hydride; acetic acid; potassium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.joc.8b00475
