Oxazolo[4,5-c]pyridine-2(3H)-thione

Base Information

• Chemical Name: Oxazolo[4,5-c]pyridine-2(3H)-thione
• CAS No.: 120640-76-8
• Molecular Formula: C6H4N2OS
• Molecular Weight: 152.177
• Hs Code.: 2934999090
• Mol file: 120640-76-8.mol

Synonyms:

Chemical Property of Oxazolo[4,5-c]pyridine-2(3H)-thione

Chemical Property:

• PSA: 77.72000
• LogP: 1.51150
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

oxazolo[4,5-c]pyridine-2(3H)-thione 95-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxazolo[4,5-c]pyridine-2(3H)-thione

There total 1 articles about Oxazolo[4,5-c]pyridine-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → 2-mercaptooxazolo[4,5-c]pyridine (120640-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 1.5 h / 2585.7 Torr

2: ethanol / 18 h / Heating

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00122a073

Reference yield:

6-bromo-N-(2,6-diisopropylphenyl)hexanamide (199592-72-8) + 2-mercaptooxazolo[4,5-c]pyridine (120640-76-8) → N-(2,6-diisopropylphenyl)-6-(oxazolo[4,5-c]pyridin-2-ylthio)hexanamide (213684-59-4)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1016/j.bmc.2018.06.024

Reference yield:

Bromodiphenylmethane (776-74-9) + 2-mercaptooxazolo[4,5-c]pyridine (120640-76-8) → 2-Benzhydrylsulfanyl-oxazolo[4,5-c]pyridine

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2.5h;

DOI:10.1016/S0968-0896(98)00103-5

upstream raw materials:

4-hydroxy-3-nitropyridine

Downstream raw materials:

N-(2,6-diisopropylphenyl)-6-(oxazolo[4,5-c]pyridin-2-ylthio)hexanamide

Refernces