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776-74-9

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776-74-9 Usage

Uses

Different sources of media describe the Uses of 776-74-9 differently. You can refer to the following data:
1. Benzhydryl Bromide is used as a reagent in the synthesis of O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors.
2. Benzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.

Chemical Properties

ORANGE-RED TO ORANGE-BROWN LOW MELTING SOLID

General Description

Bromodiphenylmethane is a white crystalline solid. Melting point 113°F. A lachrymator. In the presence of moisture corrosive to tissue and most metals.

Air & Water Reactions

Insoluble in cold water. Decomposed by hot water to give corrosive hydrobromic acid.

Reactivity Profile

Halogenated aliphatic compounds are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

A corrosive, irritating liquid, When heated to decomposition it emits toxic fumes of Br-. See also

Check Digit Verification of cas no

The CAS Registry Mumber 776-74-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 776-74:
(5*7)+(4*7)+(3*6)+(2*7)+(1*4)=99
99 % 10 = 9
So 776-74-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H10.CH3Br/c1-3-7-11(8-4-1)12-9-5-2-6-10-12;1-2/h1-10H;1H3

776-74-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Price
  • Detail
  • Alfa Aesar

  • (L02211)  Benzhydryl bromide, 90+%   

  • 776-74-9

  • 25g

  • 179.0CNY

  • Detail
  • Alfa Aesar

  • (L02211)  Benzhydryl bromide, 90+%   

  • 776-74-9

  • 100g

  • 525.0CNY

  • Detail
  • Alfa Aesar

  • (L02211)  Benzhydryl bromide, 90+%   

  • 776-74-9

  • 500g

  • 1994.0CNY

  • Detail

776-74-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Bromodiphenylmethane

1.2 Other means of identification

Product number -
Other names DIPHENYLBROMOMETHANE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:776-74-9 SDS

776-74-9Relevant articles and documents

One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride

Epifanov, Maxim,Mo, Jia Yi,Dubois, Rudy,Yu, Hao,Sammis, Glenn M.

, p. 3768 - 3777 (2021/03/01)

Sulfuryl fluoride is a valuable reagent for the one-pot activation and derivatization of aliphatic alcohols, but the highly reactive alkyl fluorosulfate intermediates limit both the types of reactions that can be accessed as well as the scope. Herein, we report the SO2F2-mediated alcohol substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides can also be exploited in the one-pot deoxygenation of primary alcohols under mild conditions (52-95% yield). This strategy can also enhance the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alcohol activation and enables substitution of primary and secondary alcohols in 54-95% yield. Chiral secondary alcohols undergo a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.

Understanding the effects of ionic liquids on a unimolecular substitution process: Correlating solvent parameters with reaction outcome

Gilbert, Alyssa,Haines, Ronald S.,Harper, Jason B.

supporting information, p. 675 - 682 (2019/01/24)

A unimolecular substitution process was studied in five different ionic liquids, with systematic variation of either the cation or anion, in order to determine the factors leading to the increase in the rate constant for the process relative to acetonitrile. It was found that both components of the ionic liquid, and the proportion of the salt in the reaction mixture, affect the rate constant. Activation parameters determined for the process suggest that there is a balance between interactions of the components of the ionic liquid with both starting material and transition state. A correlation was found between the rate constant and a combination of Kamlet-Taft solvent parameters; with the polarisability of the solvent being the most significant factor. As this reaction proceeds through both unimolecular and bimolecular pathways, competition experiments determined that the unimolecular pathway for the reaction can be favoured using small amounts of ionic liquid in the reaction mixture, demonstrating the potential to control reaction mechanisms using ionic liquids.

Visible-light-mediated benzylic sp3 C-H bond functionalization to C-Br or C-N bond

Hou, Tianyuan,Lu, Ping,Li, Pixu

supporting information, p. 2273 - 2276 (2016/05/10)

A visible-light-promoted functionalization of unactivated benzylic sp3 C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions.

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