2-Chloro-3,5-dimethoxyaniline

Base Information

• Chemical Name: 2-Chloro-3,5-dimethoxyaniline
• CAS No.: 120758-03-4
• Molecular Formula: C8H10ClNO2
• Molecular Weight: 187.626
• Mol file: 120758-03-4.mol

Synonyms:2-Chloro-3,5-dimethoxyaniline;2-Chloro-3,5-dimethoxy-phenylamine;2-chloro-3,5-dimethoxybenzenamine;2-chloro-3,5-dimethoxy-aniline;2-Chlor-3,5-dimethoxy-anilin;2-chloro-3,5-dimethoxyphenylamine;

Chemical Property of 2-Chloro-3,5-dimethoxyaniline

Chemical Property:

• Boiling Point: 306.7±37.0 °C(Predicted)
• PKA: 1.81±0.10(Predicted)
• PSA: 44.48000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 2.52060
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-3,5-dimethoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3,5-dimethoxyaniline

There total 7 articles about 2-Chloro-3,5-dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-chloro-3,5-dimethoxyphenyl)acetamide (573704-48-0) → 2-chloro-3,5-dimethoxy-phenylamine (120758-03-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Reflux;

DOI:10.1021/jm2006222

Reference yield: 13.0%

1-chloro-2,4-dimethoxybenzene (7051-13-0) → 5-chloro-2,4-dimethoxyaniline (97-50-7) + 2-chloro-3,5-dimethoxy-phenylamine (120758-03-4)

Guidance literature:

1-chloro-2,4-dimethoxybenzene; With sulfuric acid; hydroxylamine hydrochloride; In acetonitrile; at 25 ℃; for 0.166667h;

With hydrogenchloride; titanium(III) chloride; In water; acetonitrile; at 25 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c00598

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 2-chloro-3,5-dimethoxy-phenylamine (120758-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 20 h / 25 °C

2.1: hydrogenchloride; acetic acid / water / 60 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol / 2 h / Reflux

With hydrogenchloride; acetic acid; potassium hydroxide; In ethanol; water; toluene;

DOI:10.1021/jm2006222

upstream raw materials:

(2-chloro-3,5-dimethoxy-phenyl)-carbamic acid tert-butyl ester

N-(2-chloro-3,5-dimethoxyphenyl)acetamide

3.5-dimethoxyaniline

N-(3,5-dimethoxy-phenyl)-acetamide

Downstream raw materials:

2-chloro-3,5-dimethoxy-N-[1-(2,4,6-trifluorophenyl)propylidene]benzenamine

C₉H₈ClNO₃