97-50-7

Basic information

• Product Name: 5-Chloro-2,4-dimethoxyaniline
• Synonyms: CHLORODIMETHOXYANILINE;ITR AMINE;5-CHLORO-2-METHOXY-P-ANISIDINE;5-CHLORO-2,4-DIMETHOXYANILINE;5-CHLOR-2,4 DIMETHOXY ANILINE;4-AMINO-6-CHLORO-1,3-DIMETHOXYBENZENE;4-AMINO-6-CHLORORESORCINOL DIMETHYL ETHER;2,4-DIMETHOXY-5-CHLORANILINE
• CAS NO: 97-50-7
• Molecular Formula: C₈H₁₀ClNO₂
• Molecular Weight: 187.62
• EINECS: 202-586-5
• Product Categories: Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites
• Mol File: 97-50-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 89-92 °C
• Boiling Point: 305.4 °C at 760 mmHg
• Flash Point: 138.5 °C
• Appearance: Paple purple/Solid
• Density: 1.2384 (rough estimate)
• Vapor Pressure: 0.000824mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• BRN: 2211013
• CAS DataBase Reference: 5-Chloro-2,4-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2,4-dimethoxyaniline(97-50-7)
• EPA Substance Registry System: 5-Chloro-2,4-dimethoxyaniline(97-50-7)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-51/53
• Safety Statements: 37/39-26-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 9
• Hazardous Substances Data: 97-50-7(Hazardous Substances Data)

Usage

Uses

5-Chloro-2,4-dimethoxyaniline is a reagent used in the synthesis of anti-leishmaniasis agents such as 4-arylamino-6-nitroquinazoles.

InChI:InChI=1/C8H10ClNO2/c1-11-7-4-8(12-2)6(10)3-5(7)9/h3-4H,10H2,1-2H3

Upstream product

• 119-21-1 1-chloro-2,4-dimethoxy-5-nitrobenzene 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 
• 100191-30-8 4-chloro-2,5-dinitro-aniline 
• 619-18-1 2,5-dinitroaniline 
• 38411-17-5 2,5-dchloro-4-nitroacetanilide 
• 6627-34-5 2,5-dichloro-4-nitroaniline 
• 881-51-6 N-(4-chloro-2-nitrophenyl)-acetamide 
• 17488-25-4 1,4-dichloro-2,5-dinitrobenzene 
• 106-46-7 para-dichlorobenzene 
• 89-69-0 2,4,5-Trichloronitrobenzene 

Downstream Products

• 92-72-8 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide 
• 92194-70-2 <(5-Chlor-2,4-dimethoxy-anilino)-methylen>-cyanessigsaeureaethylester 
• 250718-99-1 C₁₃H₁₆O₃NCl 
• 62373-11-9 2-(5-chloro-2,4-dimethoxyanilino)-4H-3,1-benzothiazine 
• 24605-23-0 2-chloro-5-methoxybenzoquinone 
• 644972-96-3 benzoic acid-(5-chloro-2,4-dimethoxy-anilide) 
• 21970-90-1 5-Chlor-2,4-dimethoxyacetanilid 
• 87701-48-2 2-amino-4-chloro-5-methoxyphenol 
• 92-21-7 3,3'-dioxo-3,3'-p-phenylene-di-propionic acid bis-(5-chloro-2,4-dimethoxy-anilide) 
• 109448-10-4 N-(5-chloro-2,4-dimethoxy-phenyl)-6-nitro-isophthalamic acid methyl ester 
• 71862-07-2 5-Chlor-2,4-dimethoxy-formanilid 
• 140112-56-7 (Z)-Octadec-9-enoic acid (5-chloro-2,4-dimethoxy-phenyl)-amide 

Relevant articles and documents

C-H Amination of Arenes with Hydroxylamine

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.