N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Base Information

Chemical Name:N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide
CAS No.:120823-45-2
Molecular Formula:C17H18N2O3S
Molecular Weight:330.408
Hs Code.:
DSSTox Substance ID:DTXSID70547452
Wikidata:Q82425685
Mol file:120823-45-2.mol

Synonyms:120823-45-2;N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide;SCHEMBL2947799;DTXSID70547452;AKOS001310696;Z45538844;N-[2-(1H-Indol-3-yl)ethyl]-4-methoxybenzene-1-sulfonamide;N-[2-(1H-INDOL-3-YL)ETHYL]-4-METHOXY-1-BENZENESULFONAMIDE

Suppliers and Price of N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:330.10381361
Heavy Atom Count:23
Complexity:469

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)NCCC2=CNC3=CC=CC=C32

Technology Process of N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

There total 6 articles about N-(2-(1H-Indol-3-yl)ethyl)-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 61-54-1
tryptamine

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 120823-45-2
N-(2-(1H-indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/cmdc.201402428

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 120823-45-2
N-(2-(1H-indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / 4 h / 105 °C

2: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.5 h / 20 °C

3: hydrogen; palladium 10% on activated carbon / 12 h / 40 °C

4: triethylamine / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; ammonium acetate; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.08.041

Reference yield:

: 120-72-9
indole

: 120823-45-2
N-(2-(1H-indol-3-yl)ethyl)-4-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 35 °C

2: ammonium acetate / 4 h / 105 °C

3: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.5 h / 20 °C

4: hydrogen; palladium 10% on activated carbon / 12 h / 40 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; ammonium acetate; hydrogen; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.08.041