1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione

Base Information

• Chemical Name: 1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione
• CAS No.: 121239-89-2
• Molecular Formula: C18H14O4
• Molecular Weight: 294.307
• DSSTox Substance ID: DTXSID101260573
• Nikkaji Number: J1.924.000B
• Mol file: 121239-89-2.mol

Synonyms:1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione;DTXSID101260573;121239-89-2

Chemical Property of 1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 294.08920892
• Heavy Atom Count: 22
• Complexity: 414

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C#CC(=O)C2=CC=C(C=C2)OC

Technology Process of 1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione

There total 6 articles about 1,4-Bis(4-methoxyphenyl)-2-butyne-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2-dibromo-1,2-di(4-methoxybenzoyl)ethane (874525-31-2) → 1,4-bis (4-methoxyphenyl)-2-butyne-1,4-dione (121239-89-2)

Guidance literature:

With triethylamine; In benzene; for 5h; Heating;

Reference yield: 28.0%

1,4-bis(4-methoxyphenyl)-1,3-butadiyne (22779-05-1) → 1,4-bis (4-methoxyphenyl)-2-butyne-1,4-dione (121239-89-2) + 1,4-bis (4-methoxyphenyl)-3-butyne-1,2-dione (127388-14-1)

Guidance literature:

With lithium perchlorate; In N,N-dimethyl-formamide; acetonitrile; electro-oxidation, graphite plate electrode;

DOI:10.1039/c39900000445

Reference yield:

4-methoxyphenylacetylen (768-60-5) → 1,4-bis (4-methoxyphenyl)-2-butyne-1,4-dione (121239-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / cupric acetate / methanol; pyridine

2: 12 percent / LiClO₄ / acetonitrile; dimethylformamide / 90 h / anodic oxidation

With copper diacetate; lithium perchlorate; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4020(01)87069-1

upstream raw materials:

1,4-bis(4-methoxyphenyl)-1,3-butadiyne

1,2-dibromo-1,2-di(4-methoxybenzoyl)ethane

methoxybenzene

trans-1,2-di(4-methoxybenzoyl)ethylene

Downstream raw materials:

2-anilino-1,4-bis-(4-methoxy-phenyl)-but-2-ene-1,4-dione

3,4-di(4-methoxybenzoyl)-1,2,5-thiadiazole

(4-Methoxy-phenyl)-[6-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepin-8-yl]-methanone

2,5-Bis(4-methoxyphenyl)furan