4-(2,3-epoxypropoxy)-TEMPO

Base Information

• Chemical Name: 4-(2,3-epoxypropoxy)-TEMPO
• CAS No.: 122413-85-8
• Molecular Formula: C12H22NO3
• Molecular Weight: 230.327
• European Community (EC) Number: 878-648-6
• Nikkaji Number: J2.202.781F
• Mol file: 122413-85-8.mol

Synonyms:122413-85-8;4-(2,3-epoxypropoxy)-TEMPO;1-Piperidinyloxy, 2,2,6,6-tetramethyl-4-(oxiranylmethoxy)- (9CI);AKOS022101830;CS-0111495;4-Glycidyloxy-2,2,6,6-tetramethylpiperidine1-OxylFreeRadical

Chemical Property of 4-(2,3-epoxypropoxy)-TEMPO

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.15996856
• Heavy Atom Count: 16
• Complexity: 247

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CC(N1[O])(C)C)OCC2CO2)C

Technology Process of 4-(2,3-epoxypropoxy)-TEMPO

There total 2 articles about 4-(2,3-epoxypropoxy)-TEMPO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

TEMPOL (45985-24-8,2226-96-2) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-glycidyloxy-2,2,6,6-tetramethylpiperidine 1-oxyl (122413-85-8)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; at 20 ℃;

DOI:10.1021/ja061284b

Reference yield: 80.0%

tempol (2226-96-2) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-glycidyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl, (122413-85-8)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; at 30 ℃; for 4h;

DOI:10.1016/j.polymer.2014.06.064

Reference yield: 99.0%

4-glycidyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl, (122413-85-8) + phenylacetylene (536-74-3) → (E)-2,2,6,6-tetramethyl-1-((2-nitro-1-phenylvinyl)oxy)-4-(oxiran-2-ylmethoxy)piperidine

Guidance literature:

With tert.-butylnitrite; In tetrahydrofuran; at 70 ℃; for 24h; stereoselective reaction;

DOI:10.1021/ol5030585

upstream raw materials:

TEMPOL

epichlorohydrin

tempol