Tempol

Base Information

Chemical Name:Tempol
CAS No.:2226-96-2
Deprecated CAS:105269-77-0,119227-61-1,13075-58-6,3174-32-1,38854-37-4,68541-96-8,70939-25-2,900145-52-0,908588-62-5,1292766-63-2,119227-61-1,1292766-63-2,13075-58-6,38854-37-4,68541-96-8,70939-25-2,900145-52-0,908588-62-5
Molecular Formula:C9H18NO2
Molecular Weight:174.263
Hs Code.:29333999
European Community (EC) Number:218-760-9
UNII:U78ZX2F65X
DSSTox Substance ID:DTXSID4041280
Nikkaji Number:J119.381C
NCI Thesaurus Code:C96428
Metabolomics Workbench ID:153436
ChEMBL ID:CHEMBL607023
Mol file:2226-96-2.mol

Synonyms:2,2,6,6-tetramethyl-4-piperidinol-N-oxyl;4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine;4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl;4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical;4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy;HyTEMPO;N-Oxyl-2,2,6,6-tetramethylpiperidine;nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxyl;nitroxyl-2 (2,2,6,6-tetramethyl 4-oxypiperidine)-1-oxyl;tanol;tempol;TMPN

Suppliers and Price of Tempol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Tempol
100mg
$ 290.00

TRC
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy
100g
$ 425.00

Tocris
Tempol ≥99%
100
$ 64.00

TCI Chemical
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical >98.0%(GC)
5g
$ 60.00

TCI Chemical
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical >98.0%(GC)
25g
$ 180.00

Sigma-Aldrich
4-Hydroxy-TEMPO 97%
25g
$ 246.00

Sigma-Aldrich
4-Hydroxy-TEMPO 97%
1g
$ 28.30

Sigma-Aldrich
TEMPOL - CAS 2226-96-2 - Calbiochem
500mg
$ 89.30

Sigma-Aldrich
4-Hydroxy-TEMPO 97%
5g
$ 81.00

Oakwood
4-Hydroxy-2,2,6,6-tetramethyl piperidinyloxy free radical
500g
$ 137.00

Total 178 raw suppliers

Chemical Property of Tempol

Chemical Property:

Appearance/Colour:orange crystals
Vapor Pressure:0.025Pa at 20℃
Melting Point:69-71 °C(lit.)
Refractive Index:1.4350 (estimate)
Boiling Point:269ºC
PKA:5.07[at 20 ℃]
Flash Point:146°(295°F)
PSA：23.47000
Density:1.187 g/cm3
LogP:1.28370
Storage Temp.:2-8°C
Solubility.:1670g/l
Water Solubility.:soluble
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:172.133753817
Heavy Atom Count:12
Complexity:159

Purity/Quality:

99% , ^*data from raw suppliers

Tempol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xn,Xi
Statements: 22-36/37/38-36/38
Safety Statements: 26-36-37/39-36/37/39-27

MSDS Files:

Useful:

Chemical Classes:Nitrogen Compounds -> Amine Oxides
Canonical SMILES:CC1(CC(CC(N1[O])(C)C)O)C
Recent ClinicalTrials:Study to Evaluate the Effects of Tempol (MBM-02) in COVID-19 Patients.
Description TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.
Uses A free radical scavenger Spin label for EPR studies; phase transfer dehydration catalyst; antioxidant; inhibitor of olefin free radical polymerization. Tempol, a water-soluble piperidine nitroxide derivative having nonspecific radical-scavenging and superoxide dismutase (SOD) activity, protects cultured aerobic, but not hypoxic, cells against radiation-induced killing. Protection does not depend on intracellular thiols and does not involve O2-depletion. Tempol reacts with peroxyl radicals and can also oxidize DNA-bound metal ions, thereby interfering with OH? generation.

Technology Process of Tempol

There total 23 articles about Tempol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%