8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo-

Base Information

Chemical Name:8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo-
CAS No.:122601-47-2
Molecular Formula:C₁₆H₂₃NO₃S
Molecular Weight:309.43
Hs Code.:

Synonyms:

Suppliers and Price of 8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo-

There total 10 articles about 8-Azabicyclo[3.2.1]octane-3-methanol, 8-methyl-, 4-methylbenzenesulfonate (ester), endo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60873-19-0
(1R,5R,6S)-6-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one

: 122601-47-2
3α-hydroxymethyltropane tosylate

Guidance literature:: Multi-step reaction with 10 steps

1: 97 percent / pyridine

2: 1) t-BuOK / 1) THF, 0 deg C, 20 min, 2) THF, 25 deg C, 50 min

3: 89 percent / 0.18 N NaOH / 12 h / 25 °C

4: 1) triphenylmethane, n-BuLi / 1) THF, 0 deg C, 10 min, 2) THF, 0 deg C, 2.5 h

5: 1) disiamylborane, 2) 30percent aq. H₂O₂, 3 N NaOH / 1) THF, 0 deg C, 30 min, 2) methanol, 0 deg C

6: 99 percent / TsOH*H₂O / 2.5 h / 0 °C

7: potassium t-BuOK / dimethylsulfoxide / 25 °C

8: 0.1 N aq. HCl / methanol / 0.75 h

9: 1.7 mg / H₂ / 10 percent Pd on charcoal / methanol / 2.5 h / 1344.6 - 2223.7 Torr / Ambient temperature

10: 1) triphenylmethane, n-BuLi

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; triphenylmethane; potassium tert-butylate; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)81578-7

Reference yield:

: 142892-43-1
3α-hydroxymethyltrop-6-ene tetrahydropyranyl ether

: 122601-47-2
3α-hydroxymethyltropane tosylate

Guidance literature:: Multi-step reaction with 3 steps

1: 0.1 N aq. HCl / methanol / 0.75 h

2: 1.7 mg / H₂ / 10 percent Pd on charcoal / methanol / 2.5 h / 1344.6 - 2223.7 Torr / Ambient temperature

3: 1) triphenylmethane, n-BuLi

With hydrogenchloride; n-butyllithium; triphenylmethane; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0040-4020(01)81578-7

Reference yield:

: 142892-38-4
3-methylenetropan-6β-ol tosylate

: 122601-47-2
3α-hydroxymethyltropane tosylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1) disiamylborane, 2) 30percent aq. H₂O₂, 3 N NaOH / 1) THF, 0 deg C, 30 min, 2) methanol, 0 deg C

2: 99 percent / TsOH*H₂O / 2.5 h / 0 °C

3: potassium t-BuOK / dimethylsulfoxide / 25 °C

4: 0.1 N aq. HCl / methanol / 0.75 h

5: 1.7 mg / H₂ / 10 percent Pd on charcoal / methanol / 2.5 h / 1344.6 - 2223.7 Torr / Ambient temperature

6: 1) triphenylmethane, n-BuLi

With hydrogenchloride; sodium hydroxide; n-butyllithium; triphenylmethane; potassium tert-butylate; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)81578-7