endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol

Base Information

Chemical Name:endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol
CAS No.:142892-37-3
Molecular Formula:C9H17 N O
Molecular Weight:155.24
Hs Code.:
Mol file:142892-37-3.mol

Synonyms:8-Azabicyclo[3.2.1]octane-3-methanol,8-methyl-, endo-

Suppliers and Price of endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ENDO-(8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL)METHANOL 95.00%
5MG
$ 497.55

Total 37 raw suppliers

Chemical Property of endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol

Chemical Property:

Vapor Pressure:0.011mmHg at 25°C
Boiling Point:232oC
Flash Point:98 ºC
PSA：23.47000
Density:1.017
LogP:0.78940

Purity/Quality:

98% ^*data from raw suppliers

ENDO-(8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol

There total 11 articles about endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 273376-39-9
tert-butyl rel-(1R,3r,5S)-3-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 142892-37-3
((endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 80 ℃; for 1h; Microwave irradiation;

Reference yield:

: 142892-44-2
3α-hydroxymethyltrop-6-ene

: 142892-37-3
((endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)methanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2.5h; under 1344.6 - 2223.7 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)81578-7

Reference yield:

: 60873-19-0
(1R,5R,6S)-6-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one

: 142892-37-3
((endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / pyridine

2: 1) t-BuOK / 1) THF, 0 deg C, 20 min, 2) THF, 25 deg C, 50 min

3: 89 percent / 0.18 N NaOH / 12 h / 25 °C

4: 1) triphenylmethane, n-BuLi / 1) THF, 0 deg C, 10 min, 2) THF, 0 deg C, 2.5 h

5: 1) disiamylborane, 2) 30percent aq. H₂O₂, 3 N NaOH / 1) THF, 0 deg C, 30 min, 2) methanol, 0 deg C

6: 99 percent / TsOH*H₂O / 2.5 h / 0 °C

7: potassium t-BuOK / dimethylsulfoxide / 25 °C

8: 0.1 N aq. HCl / methanol / 0.75 h

9: 1.7 mg / H₂ / 10 percent Pd on charcoal / methanol / 2.5 h / 1344.6 - 2223.7 Torr / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; triphenylmethane; potassium tert-butylate; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)81578-7