3-Pyridinecarboxylic acid, 1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl ester
CAS No.:122956-80-3
Molecular Formula:C35H29F3N6O4
Molecular Weight:654.648
Hs Code.:

3-Pyridinecarboxylic acid,
1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen
yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl
ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl ester

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Technology Process of 3-Pyridinecarboxylic acid, 1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl ester

There total 9 articles about 3-Pyridinecarboxylic acid, 1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phen yl]-5-[(2-pyridinylamino)carbonyl]-4-[2-(trifluoromethoxy)phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 60155-47-7
N-(2-pyridyl)-3-aminocrotonamide

: 122957-08-8
ethyl 4'-(2-methylimidazo[4,5-c]pyridin-1-yl)benzoylacetate

: 122956-80-3
6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-4-(2-trifluoromethoxy-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1021/jm00095a005

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 122956-80-3
6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-4-(2-trifluoromethoxy-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 81 percent / acetic acid / 2 h / 90 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

5: 4 percent / ethanol / 8 h / Heating

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00095a005

Reference yield:

: 122957-33-9
4-[N-(4-cyanophenyl)amino]-3-nitropyridine

: 122956-80-3
6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-4-(2-trifluoromethoxy-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

2: 81 percent / acetic acid / 2 h / 90 °C

3: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

4: 4 percent / ethanol / 8 h / Heating

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00095a005