13091-23-1Relevant academic research and scientific papers
CHLORINE-ISOTOPIC EXCHANGE BETWEEN LITHIUM CHLORIDE AND SUBSTITUTED 2-CHLOROPYRIDINE IN HOMOGENEOUS SOLUTION
Gore, Peter H.,Hundal, Apparapar S.,Morris, Donald F. C.
, p. 167 - 171 (1981)
The kinetics of chlorine-isotopic exchange between lithium chloride-36 and cyano- and nitro-substituted 2-chloropyridines were measured in sulpholane, acetone or methanol solution.Activating effects of ortho-nitro and ortho-azu substitution are compared: a nitro-group is 50 x as activating as the aza-group in the p-nitrochlorobenzene system, whereas it is the aza-function which is 3 times as activiting as the nitro group in the o-nitrochlorobenzene system.The effect of Me substituents placed ortho to an activating nitro-group was studied by comparing 2-chloro-3-cyano-5-nitropyridine and its 6-methyl- and 4,6-dimethyl derivatives.
Hydrophobic metallo-supramolecular Pd2L4 cages for zwitterionic guest encapsulation in organic solvents
Li, Yu-Hao,Zhang, Yan,Legrand, Yves-Marie,Van Der Lee, Arie,Jiang, Ji-Jun,Chen, Cheng-Xia,Su, Cheng-Yong,Barboiu, Mihail
, p. 15204 - 15207 (2017)
Hydrophilic zwitterionic guest encapsulation by metallo-supramolecular cages through synergetic coordination, H-bonding and hydrophobic interactions.
Synthetic method of active intermediate 4-chloro-3-nitropyridine
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Paragraph 0013; 0019; 0025, (2021/04/28)
The invention discloses a synthetic method of active intermediate 4-chloro-3-nitropyridine. The method comprises the following steps: step 1, adding 24L of concentrated sulfuric acid into a 50L reaction kettle, cooling to about 10 DEG C, adding 4kg of raw materials in batches, carrying out HPLC detection on the end of the reaction of the raw materials on the next day, carrying out aftertreatment, slowly pouring the reaction liquid into 30L of ice water for quenching, adjusting the pH value to 7, carrying out suction filtration to obtain a faint yellow solid, and carrying out suction filtration; drying to obtain 4.6 kg of 4-hydroxy-3-nitropyridine faint yellow solid with the yield of 80% and the purity of 98%; and 2, adding 500g of SM into a 10L reaction flask at room temperature, dissolving with 5L of methylbenzene, dropwise adding 1643g of phosphorus oxychloride at room temperature, dropwise adding the crude product into PE, stirring and extracting for multiple times to obtain 388g of 4-chloro-3-nitropyridine faint yellow solid with the yield of 68% and the purity of 95%. According to the synthetic method of active intermediate 4-chloro-3-nitropyridine, improvement points of the project process mainly aim at purity control and reaction stability control of the reaction in the third step, aftertreatment is simple, and product purification can be achieved through extraction.
METHOD FOR PREPARING HETEROCYCLIC DERIVATIVE COMPOUND, COMPOSITION CONTAINING SAME COMPOUND, AND HYDRATE OF SAME COMPOUND
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Paragraph 0097, (2020/04/21)
The present invention relates to: a novel method for preparing a heterocyclic derivative compound of chemical formula I below; a novel intermediate compound used in the preparation method; a composition for treatment or prevention of hyperuricacidemia, gout, nephritis, chronic renal insufficiency, nephrolith, uremia, urolithiasis, or a uric acid-related disease, the composition containing the compound of chemical formula I at a dose of more than 2 mg and equal to or less than 10 mg and being orally administered once a day; and a hydrochloride 1.5 hydrate of the novel compound of chemical formula I.
NOVEL AROMATIC COMPOUND AND USE THEREOF
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Paragraph 0330-0332, (2016/08/17)
Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or To treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.
4-chloro-3-nitropyridine and preparation method thereof
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Paragraph 0019; 0022, (2016/11/17)
The invention discloses 4-chloro-3-nitropyridine and a preparation method thereof. The preparation method is characterized in that 4-hydroxypyridine is taken as the raw material, ionic liquid is taken as a reaction medium and mesoporous silica is taken as a catalyst, and comprises the following steps: firstly, carrying out nitration reaction with nitric acid to produce 4-hydroxyl-3-nitropyridine; carrying out reaction between 4-hydroxyl-3-nitropyridine and phosphorus oxychloride under catalyzation of thionyl chloride to produce 4-chloro-3-nitropyridine. According to 4-chloro-3-nitropyridine and the preparation method thereof provided by the invention, the condition is mild and easy to control, the requirement on equipment is low, the product purity is high, and the yield is high.
High colour rendering index and colour stable hybrid white efficient OLEDs with a double emitting layer structure using a single phosphorescence dopant of heteroleptic platinum complexes
Poloek, Anurachw,Lin, Chiao-Wen,Chen, Chin-Ti,Chen, Chao-Tsen
, p. 10343 - 10356 (2015/02/19)
Four heteroleptic platinum complexes (FPtXND) bearing 4-hydroxy-1,5-naphthyridine derivatives functionalized with dimethyl (X = mm), phenoxy (X = OPh), piperidine (X = pp), or carbazole (X = Cz) units as one ligand (XND) and 2-(2,4-difluorophenyl)pyridine as the other common ligand (F) were newly synthesized and characterized. The crystal structures of FPtOPhND and FPtCzND were determined by single-crystal X-ray diffraction crystallography. Although they have a short plane-to-plane packing distance of 3.62 and 3.39 A, respectively, both platinum complexes have different molecular packing patterns, which affect their photoluminescence (PL) in solution and electroluminescence (EL) in the solid state. Due to the contribution from both monomers and excimers/aggregates, all of the platinum complexes exhibited broad and red-shifted PL in concentrated solutions as well as in doped thin films. In the monochromatic organic lighting diode (OLED) testing, FPtXND doped in 4,4′-di(9H-carbazol-9-yl)-1,1′-biphenyl (CBP) exhibited greenish yellow or orange yellow EL, of which FPtOPhND has the highest EL efficiency mainly due to its high solution PL quantum yield of 21%. Hybrid white OLEDs were first achieved with a single emitting layer configuration, of which highly fluorescent blue N,N′-di-1-naphthalenyl-N,N′-diphenyl-[1,1′:4′,1″:4″,1-quaterphenyl]-4,4-diamine (4P-NPD) was used as the host material for all four platinum complexes. To improve the performance of the FPtOPhND-based hybrid white OLEDs, double emitting layer configurations were adopted with CBP and 4P-NPD as the host material. Virtually voltage independent, a white EL having CIEx,y (0.33, 0.31) and a CRI as high as 91 was obtained. The maximum EL efficiency of 11.8%, 25.9 cd A-1, or 11.6 lm W-1 was acquired with FPtOPhND doped in the double emitting layer configuration of an OLED.
AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY
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Page/Page column 189, (2014/08/19)
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
Use of the graebe-ullmann reaction in the synthesis of 8-methyl-γ- carboline and isomeric aromatic aza-γ-carbolines
Alekseev,Kurkin,Yurovskaya
, p. 1235 - 1250 (2013/03/13)
Two variants of the Graebe-Ullmann reaction were used to obtain 8-methyl-5H-pyrido[4,3-b]indole (8-methyl-γ-carboline) and the conditions for this reaction were optimized. The feasibility of using this method was studied for the synthesis of a series of isomeric aromatic aza-γ- carbolines from the corresponding 1-(pyridyl)-1H-1,2,3-triazolo[4,5-c]pyridines under thermal and microwave irradiation conditions.
Preparation of azaindolines and benzoyl substituted azaindolines: Precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors
Badland, Matthew,Devillers, Ingrid,Durand, Corinne,Fasquelle, Véronique,Gaudillire, Bernard,Jacobelli, Henry,Manage, Ajith C.,Pevet, Isabelle,Puaud, Jocelyne,Shorter, Anthony J.,Wrigglesworth, Roger
supporting information; experimental part, p. 5292 - 5296 (2011/10/30)
The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors.
