3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
CAS No.:122956-90-5
Molecular Formula:C33H29ClN4O3
Molecular Weight:565.071
Hs Code.:
Mol file:122956-90-5.mol

3-Pyridinecarboxylic acid,
4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen
yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-3-pyridinyl)phen yl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 89-98-5
2-chloro-benzaldehyde

: 60155-47-7
N-(2-pyridyl)-3-aminocrotonamide

: 122957-20-4
3-[4-(2-Methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid ethyl ester

: 122956-90-5
4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridin-3-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1021/jm00095a005

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 122956-90-5
4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridin-3-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuLi, 2.) ZnCl₂ / 2.) Pd(PPh₃)4 / 1.) THF, pentane, -60 deg C, 20 min, 2.) THF, pentane, reflux, 5.5 h

2: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

3: 9 percent / ethanol / 8 h / Heating

With tert.-butyl lithium; trifluoroacetic acid; zinc(II) chloride; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol;
DOI:10.1021/jm00095a005

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 122956-90-5
4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridin-3-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuLi, 2.) ZnCl₂ / 2.) Pd(PPh₃)4 / 1.) THF, pentane, -60 deg C, 20 min, 2.) THF, pentane, reflux, 5.5 h

2: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

3: 9 percent / ethanol / 8 h / Heating

With tert.-butyl lithium; trifluoroacetic acid; zinc(II) chloride; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol;
DOI:10.1021/jm00095a005