((4S,5S)-2-ethoxy-1,3-dioxolane-4,5-diyl)diMethanol

Base Information

• Chemical Name: ((4S,5S)-2-ethoxy-1,3-dioxolane-4,5-diyl)diMethanol
• CAS No.: 123125-18-8
• Molecular Formula: C7H14O5
• Molecular Weight: 178.18300
• Mol file: 123125-18-8.mol

Synonyms:2-ethoxy-1,3-dioxolane-4(S),5(S)-dimethanol;L-threitol 2,3-cyclic ethyl orthoformate;

Chemical Property of ((4S,5S)-2-ethoxy-1,3-dioxolane-4,5-diyl)diMethanol

Chemical Property:

• PSA: 68.15000
• LogP: -0.92490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ((4S,5S)-2-ethoxy-1,3-dioxolane-4,5-diyl)diMethanol

There total 1 articles about ((4S,5S)-2-ethoxy-1,3-dioxolane-4,5-diyl)diMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-(R,R)-2-ethoxy-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester (162491-34-1) → (2S,3S)-1,4-dihydroxy-2,3-butanediol cyclic ethyl orthoester (123125-18-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/S0040-4020(01)89342-X

Reference yield: 39.0%

(4,4'-isopropylidenedithio)bis[2,6-di-tert-butylphenol] (23288-49-5) + (2S,3S)-1,4-dihydroxy-2,3-butanediol cyclic ethyl orthoester (123125-18-8) → 2,6-di-tert-butyl-4-{1-[3,5-di-tert-butyl-4-(2-ethoxy-5(S)-hydroxymethyl-[1,3]dioxolan-4(S)-yl-methoxy)-phenylsulfanyl]-1-methyl-ethylsulfanyl}-phenol

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jm049685u

Reference yield:

(4,4'-isopropylidenedithio)bis[2,6-di-tert-butylphenol] (23288-49-5) + (2S,3S)-1,4-dihydroxy-2,3-butanediol cyclic ethyl orthoester (123125-18-8) → 2,6-di-tert-butyl-4-{1-[3,5-di-tert-butyl-4-(2-ethoxy-5(S)-hydroxymethyl-[1,3]dioxolan-4(S)-yl-methoxy)-phenylsulfanyl]-1-methyl-ethylsulfanyl}-phenol + 2,6-di-tert-butyl-4-{1-[3,5-di-tert-butyl-4-(2-ethoxy-5(S)-hydroxymethyl-[1,3]dioxolan-4(S)-yl-methoxy)-phenylsulfanyl]-1-methyl-ethylsulfanyl}-phenol

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 3h; Heating / reflux;

upstream raw materials:

L-(R,R)-2-ethoxy-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester

Downstream raw materials:

1,4-di-O-benzyl-L-threitol 2,3-cyclic ethyl orthoformate

1,4-di-O-benzyl-2-chloro-2-deoxy-3-O-formyl-L-erythritol