5-chloro-2-(1-piperidyl)benzooxazole

Base Information

• Chemical Name: 5-chloro-2-(1-piperidyl)benzooxazole
• CAS No.: 78750-03-5
• Molecular Formula: C12H13 Cl N2 O
• Molecular Weight: 236.701
• Mol file: 78750-03-5.mol

Synonyms:Benzoxazole,5-chloro-2-piperidino- (7CI); NSC 24975

Chemical Property of 5-chloro-2-(1-piperidyl)benzooxazole

Chemical Property:

• Vapor Pressure: 2.86E-05mmHg at 25°C
• Boiling Point: 356.8°C at 760 mmHg
• Flash Point: 169.6°C
• PSA: 29.27000
• Density: 1.287g/cm³
• LogP: 3.53650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-(1-piperidyl)benzooxazole

There total 11 articles about 5-chloro-2-(1-piperidyl)benzooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C12H15ClN2O → 5-chloro-2-(piperidin-1-yl)benzoxazole (78750-03-5)

Guidance literature:

With carbon tetrabromide; In acetonitrile; at 20 ℃; for 1h; Irradiation;

DOI:10.1039/c3ra46314a

Reference yield: 66.0%

piperidin-1-yl benzoate (5542-49-4) + 5-chloro-benzoxazole (17200-29-2) → 5-chloro-2-(piperidin-1-yl)benzoxazole (78750-03-5)

Guidance literature:

With triphenylphosphine; copper(l) chloride; lithium tert-butoxide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2013.05.127

Reference yield: 63.0%

Piperidine-1-carbothioic acid (5-chloro-2-hydroxy-phenyl)-amide → 5-chloro-2-(piperidin-1-yl)benzoxazole (78750-03-5)

Guidance literature:

With ammonium hydroxide; silver nitrate; In ethanol; at 40 - 50 ℃; for 12h;

DOI:10.1007/BF00505682

upstream raw materials:

piperidine

5-chloro-2-methylsulfanyl-benzooxazole

5-chloro-2-mercaptobenzoxazole

2-hydroxy-5-chloro-aniline