5-Chloro-2-(methylthio)benzoxazole

Base Information

• Chemical Name: 5-Chloro-2-(methylthio)benzoxazole
• CAS No.: 64037-25-8
• Molecular Formula: C8H6 Cl N O S
• Molecular Weight: 199.661
• Hs Code.: 2934999090
• Mol file: 64037-25-8.mol

Synonyms:5-Chloro-2-(methylthio)benzoxazole;5-Chloro-2-methylsulfanylbenzoxazole; NSC 24976

Chemical Property of 5-Chloro-2-(methylthio)benzoxazole

Chemical Property:

• Vapor Pressure: 0.0011mmHg at 25°C
• Melting Point: 87-89 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 310.4°Cat760mmHg
• PKA: -0.66±0.10(Predicted)
• Flash Point: 141.5°C
• PSA: 51.33000
• Density: 1.41g/cm³
• LogP: 3.20310

Purity/Quality:

98%min ^*data from raw suppliers

5-chloro-2-(methylthio)-1,3-benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-(methylthio)benzoxazole

There total 3 articles about 5-Chloro-2-(methylthio)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-chlorobenzo[d]oxazole-2(3H)-thione (22876-19-3) + methyl iodide (74-88-4) → 5-chloro-2-methylsulfanyl-benzooxazole (64037-25-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

Reference yield: 79.0%

5-chloro-2-mercaptobenzoxazole (22876-19-3) + methyl iodide (74-88-4) → 5-chloro-2-methylsulfanyl-benzooxazole (64037-25-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetone; at 20 ℃; for 0.25h; Sonication;

DOI:10.1016/j.ultsonch.2010.03.002

Reference yield:

5-chloro-2-mercaptobenzoxazole (22876-19-3) + dimethyl sulfate (77-78-1) → 5-chloro-2-methylsulfanyl-benzooxazole (64037-25-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/jps.2600530518

upstream raw materials:

5-chloro-2-mercaptobenzoxazole

dimethyl sulfate

5-chlorobenzo[d]oxazole-2(3H)-thione

methyl iodide

Downstream raw materials:

5-chloro-2-(piperidin-1-yl)benzoxazole

2-(N-benzyl-N-phenylamino)-5-chlorobenzoxazole

5-chloro-N-phenyl-1,3-benzoxazole-2-amine

N-benzyl-5-chloro-N-methylbenzo[d]oxazol-2-amine