(R)-2-ethylpyrrolidine

Base Information

• Chemical Name: (R)-2-ethylpyrrolidine
• CAS No.: 123168-37-6
• Molecular Formula: C6H13N
• Molecular Weight: 99.1759
• DSSTox Substance ID: DTXSID00448665
• Nikkaji Number: J714.894A
• Wikidata: Q82267754
• Mol file: 123168-37-6.mol

Synonyms:(R)-2-ethylpyrrolidine;123168-37-6;(2R)-2-ETHYL-PYRROLIDINE;(2R)-2-ethylpyrrolidine;Pyrrolidine, 2-ethyl-, (R)-;2-(R)-ethyl-pyrrolidine;(R)-2alpha-Ethylpyrrolidine;DTXSID00448665;JFZLDRUSMYBXRI-ZCFIWIBFSA-N;MFCD19217252;RB4030;AKOS006348967

Chemical Property of (R)-2-ethylpyrrolidine

Chemical Property:

• PSA: 12.03000
• LogP: 1.47720
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 99.104799419
• Heavy Atom Count: 7
• Complexity: 52.1

Purity/Quality:

97% ^*data from raw suppliers

(2R)-2-Ethyl-pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CCCN1
• Isomeric SMILES: CC[C@@H]1CCCN1

Technology Process of (R)-2-ethylpyrrolidine

There total 6 articles about (R)-2-ethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

phenylmethyl (2R)-2-ethyl-1-pyrrolidinecarboxylate (1227910-54-4) → (R)-2-Ethylpyrrolidine (123168-37-6)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 90 ℃; for 5h; Sealed tube;

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → (R)-2-Ethylpyrrolidine (123168-37-6)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0040-4039(96)00056-1

Reference yield:

tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate (876617-06-0) → (R)-2-Ethylpyrrolidine (123168-37-6)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 0.5h; Yield given;

DOI:10.1021/ja00202a037

upstream raw materials:

tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate

(S)-Pyroglutaminol

(2R)-2-[(2'R)-2'-ethyl-N-pyrrolidinyl]-2-phenyl-1-ethanol

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate