(R)-tert-butyl 2-ethylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2-ethylpyrrolidine-1-carboxylate
• CAS No.: 876617-06-0
• Molecular Formula: C₁₁H₂₁NO₂
• Molecular Weight: 199.293
• Hs Code.: 2933990090
• Mol file: 876617-06-0.mol

Synonyms:QC-579;RB4033;2R-ethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;

Chemical Property of (R)-tert-butyl 2-ethylpyrrolidine-1-carboxylate

Chemical Property:

• PSA: 29.54000
• LogP: 2.73380
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl 2-ethylpyrrolidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 2-ethylpyrrolidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 2-ethylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-2-vinylpyrrolidine-1-carboxylate (115393-77-6) → tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate (876617-06-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 20h;

Reference yield:

methyllithium (917-54-4) + (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate (86661-32-7) → tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate (876617-06-0)

Guidance literature:

With copper(l) iodide; In diethyl ether; dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/ja00202a037

Reference yield:

methyllithium (917-54-4) + tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate (132482-09-8) → tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate (876617-06-0)

Guidance literature:

With copper(l) iodide; In diethyl ether; at -20 - -15 ℃;

upstream raw materials:

methyllithium

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-vinylpyrrolidine-1-carboxylate

tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate

Downstream raw materials:

(R)-2-Ethylpyrrolidine

(2R)-2-ethylpyrrolidine hydrochloride

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