Quinoline, 2-(4-chlorophenyl)-4-phenyl-

Base Information

• Chemical Name: Quinoline, 2-(4-chlorophenyl)-4-phenyl-
• CAS No.: 1236-90-4
• Molecular Formula: C21H14ClN
• Molecular Weight: 315.802
• Mol file: 1236-90-4.mol

Synonyms:

Chemical Property of Quinoline, 2-(4-chlorophenyl)-4-phenyl-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 2-(4-chlorophenyl)-4-phenyl-

There total 31 articles about Quinoline, 2-(4-chlorophenyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-styrenyloxytrimethylsilane (13735-81-4) + (E)-1-(4-chlorophenyl)-N-phenylmethanimine (1613-95-2) → 2-(4-chlorophenyl)-4-phenylquinoline (1236-90-4)

Guidance literature:

1-styrenyloxytrimethylsilane; (E)-1-(4-chlorophenyl)-N-phenylmethanimine; With trifluorormethanesulfonic acid; In acetonitrile; at 20 ℃; for 3h;

With manganese triacetate; In acetic acid; acetonitrile; at 20 ℃; for 24h;

DOI:10.1246/cl.2004.922

Reference yield: 93.0%

2-iodo-4'-chloroacetophenone (53896-48-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-(4-chlorophenyl)-4-phenylquinoline (1236-90-4)

Guidance literature:

2-iodo-4'-chloroacetophenone; (2-aminophenyl)(phenyl)methanone; With trimethylsilyl trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 0 ℃; Heating; Sealed;

With water; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Sonication;

DOI:10.1021/jo2008252

Reference yield: 92.0%

para-chloroacetophenone (99-91-2) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-(4-chlorophenyl)-4-phenylquinoline (1236-90-4)

Guidance literature:

With propylsulfonic silica; at 80 ℃; for 1.5h; Neat (no solvent); Microwave irradiation;

DOI:10.1080/00397910902957407

upstream raw materials:

(E)-1-(4-chlorophenyl)-N-phenylmethanimine

phenylacetylene

4-chloroacetophenone oxime

(2-aminophenyl)(phenyl)methanone

Refernces

• 1、 Gao, Ziwei,Jian, Yajun,Sun, Huaming,Wang, Yanyan,Yang, Mingming,Zhang, Guofang,Zhang, Weiqiang. "Synthesis of quinolines: Via sequential addition and I2-mediated desulfurative cyclization". supporting information. p. 38889 - 38893. Retrieved 2021/12/20.
• 2、 Gajare, Shivanand,Patil, Audumbar,Hangirgekar, Shankar,Dhanmane, Sushilkumar,Rashinkar, Gajanan. "Green synthesis of quinolines via A3-coupling by using graphene oxide-supported Br?nsted acidic ionic liquid". . p. 2417 - 2436. Retrieved 2020/02/18.