Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester

Base Information

Chemical Name:Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester
CAS No.:124286-43-7
Molecular Formula:C16H20O5
Molecular Weight:292.332
Hs Code.:
DSSTox Substance ID:DTXSID40463857
Nikkaji Number:J275.876H
Wikidata:Q82288925
Mol file:124286-43-7.mol

Synonyms:Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester;124286-43-7;DTXSID40463857

Suppliers and Price of Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:292.13107373
Heavy Atom Count:21
Complexity:364

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)(CC(=O)C1=CC=CC=C1)C(=O)OCC

Technology Process of Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester

There total 3 articles about Propanedioic acid, methyl(2-oxo-2-phenylethyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 29263-94-3
diethyl bromomethylmalonate

: 78386-38-6
1-tert-butoxy-1-phenylethene

: 124286-43-7
diethyl 2-methyl-2-(2-oxo-2-phenylethyl)malonate

Guidance literature:: With 2,4,6-trimethyl-pyridine; 2,2'-azobis(isobutyronitrile); In benzene; for 3h; Heating;
DOI:10.1016/S0040-4039(03)01092-X

Reference yield: 75.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 609-08-5
Diethyl methylmalonate

: 124286-43-7
diethyl 2-methyl-2-(2-oxo-2-phenylethyl)malonate

Guidance literature:: With copper diacetate; In dimethylsulfoxide-d6; at 120 ℃; for 24h; Schlenk technique;
DOI:10.1021/acs.orglett.9b00142

Reference yield:

: 609-08-5
Diethyl methylmalonate

: 124286-43-7
diethyl 2-methyl-2-(2-oxo-2-phenylethyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: Me₃COLi / hexamethylphosphoric acid triamide

2: 61 percent / hexamethylphosphoric acid triamide / 2 h / Irradiation

With lithium tert-butoxide; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00290a050