(S)-Benproperine

Base Information

• Chemical Name: (S)-Benproperine
• CAS No.: 124700-66-9
• Molecular Formula: C21H27NO
• Molecular Weight: 309.44500
• Mol file: 124700-66-9.mol

Synonyms:Benproperine,(S)-;Piperidine,1-((1S)-1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-;Benproperine,(-)-;

Chemical Property of (S)-Benproperine

Chemical Property:

• PSA: 12.47000
• LogP: 4.46850

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Benproperine

There total 14 articles about (S)-Benproperine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

piperidine (110-89-4) + (S)-(-)-1-(2-benzylphenoxy)propan-2-yl 4-methylbenzenesulfonate → (R)-(+)-1-[1-(2-benzylphenoxy)propan-2-yl]piperidine (124700-66-9)

Guidance literature:

at 120 ℃; for 5h;

Reference yield: 65.9%

piperidine (110-89-4) + (R)-(+)-1-(2-benzylphenoxy)propan-2-yl 4-methylbenzenesulfonate → (S)-(-)-1-[1-(2-benzylphenoxy)propan-2-yl]piperidine (124700-66-9)

Guidance literature:

at 120 ℃; for 5h;

Reference yield: 49.0%

1-(3-(2-benzylphenoxy)-2-chloropropyl)piperidine → 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine (2156-27-6,124700-66-9)

Guidance literature:

1-(3-(2-benzylphenoxy)-2-chloropropyl)piperidine; With sodium iodide; In acetonitrile; at 20 ℃; for 18h; Sealed tube; Inert atmosphere;

With lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile; at 0 ℃; for 0.0833333h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.202005652

upstream raw materials:

o-Benzylphenol

piperidine

(2-benzyl-phenyl)-(2-chloro-propyl)-ether

phenol

Downstream raw materials:

Benproperine phosphate

Refernces

• 1、 -. "A green synthetic benproperine phosphate in intermediates (by machine translation)". . . Retrieved 2018/11/22.
• 2、 -. "COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES". . . Retrieved 2013/09/26.