1-benzyl-1H-1,2,3-triazole-4-carbaldehyde

Base Information

• Chemical Name: 1-benzyl-1H-1,2,3-triazole-4-carbaldehyde
• CAS No.: 124940-34-7
• Molecular Formula: C10H9N3O
• Molecular Weight: 187.201
• Hs Code.: 2933990090
• Mol file: 124940-34-7.mol

Synonyms:1-benzyl-1,2,3-triazole-4-carbaldehyde;benzyltriazolecarbaldehyde;1-benzyl-1H-1,2,3-triazole-4-carbaldehyde;1-benzyl-4-formyl-1H-1,2,3-triazole;1-benzyl-4-formyl-1,2,3-triazole;1-Benzyl-1H-[1,2,3]triazol-4-carbaldehyd;

Chemical Property of 1-benzyl-1H-1,2,3-triazole-4-carbaldehyde

Chemical Property:

• Melting Point: 86～88℃
• PSA: 47.78000
• LogP: 1.13890

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-1H-1,2,3-triazole-4-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl-1H-1,2,3-triazole-4-carbaldehyde

There total 36 articles about 1-benzyl-1H-1,2,3-triazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromoacrolein (14925-39-4) + benzyl azide (622-79-7) → 1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxaldehyde (124940-34-7)

Guidance literature:

2-bromoacrolein; benzyl azide; In water; dimethyl sulfoxide; at 20 ℃; for 36h;

With triethylamine; In water; dimethyl sulfoxide; at 20 ℃; for 0.0833333h; regioselective reaction;

DOI:10.1039/c9gc01129c

Reference yield: 92.0%

(1-benzyl-[1,2,3]triazol-4-yl)methanol (28798-81-4) → 1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxaldehyde (124940-34-7)

Guidance literature:

With manganese(IV) oxide; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2016.12.074

Reference yield: 90.0%

Propargylic aldehyde (624-67-9) + benzyl bromide (100-39-0) → 1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxaldehyde (124940-34-7)

Guidance literature:

With sodium azide; copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 120 ℃; for 0.2h; regioselective reaction; Microwave irradiation;

DOI:10.3998/ark.5550190.0012.913

upstream raw materials:

Propargylic aldehyde

benzyl azide

(1-benzyl-[1,2,3]triazol-4-yl)methanol

[1-(1-Benzyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-phenyl-amine

Downstream raw materials:

N,N-bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]prop-2-yn-1-amine

Refernces

• 1、 Rono, Charles K.,Chu, William K.,Darkwa, James,Meyer, Debra,Makhubela, Banothile C. E.. "Triazolyl RuII, RhIII OsII, and IrIII Complexes as Potential Anticancer Agents: Synthesis, Structure Elucidation, Cytotoxicity, and DNA Model Interaction Studies". . p. 3197 - 3211. Retrieved 2019.
• 2、 Banala, Srinivas,Kiessling, Fabian,Merkes, Jean Michel,Ostlender, Tobias,Sun, Haitao,Wang, Fufang. "Tuning the optical properties of BODIPY dyes by N-rich heterocycle conjugation using a combined synthesis and computational approach". supporting information. p. 19641 - 19645. Retrieved 2021/11/12.
• 3、 Brabec, Viktor,Clarkson, Guy J.,Coverdale, James P. C.,Kostrhunova, Hana,Phillips, Roger M.,Postings, Miles,Rogers, Nicola J.,Scott, Peter,Shepherd, Samantha L.,Song, Hualong. "Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds". supporting information. p. 6392 - 6395. Retrieved 2020/06/21.