3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate

Base Information

• Chemical Name: 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate
• CAS No.: 125314-97-8
• Molecular Formula: C26H22N2O5
• Molecular Weight: 442.46300
• Mol file: 125314-97-8.mol

Synonyms:3-[1-(3-acetoxypropyl)-3-indolyl]-4-(1-methyl-3-indolyl)-2,5-furandione;3-[1-(3-acetoxypropyl)-3-indolyl]-4-(1-methyl-3-indolyl)furan-2,5-dione;3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-furandione Acetate;

Chemical Property of 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate

Chemical Property:

• PSA: 79.53000
• LogP: 4.08040
• Storage Temp.: Refrigerator

Purity/Quality:

3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-furandioneAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Acetate is a Bisindolylmaleimides with protein kinase C inhibitor activity.

Technology Process of 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate

There total 4 articles about 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole (120-72-9) → 3-<1-(3-acetoxypropyl)-3-indolyl>-4-(1-methyl-3-indolyl)-2,5-furandione (125314-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, RT, 18 h

2: CH₂Cl₂ / 3 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1021/jm00084a004

Reference yield:

3-bromopropyl acetate (592-33-6) → 3-<1-(3-acetoxypropyl)-3-indolyl>-4-(1-methyl-3-indolyl)-2,5-furandione (125314-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, RT, 18 h

2: CH₂Cl₂ / 3 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1021/jm00084a004

Reference yield:

N-(3-acetoxypropyl)-indole (125314-98-9) → 3-<1-(3-acetoxypropyl)-3-indolyl>-4-(1-methyl-3-indolyl)-2,5-furandione (125314-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 3 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1021/jm00084a004

upstream raw materials:

2-(1-methyl-1H-indol-3-yl)acetic acid

indole

3-bromopropyl acetate

N-(3-acetoxypropyl)-indole

Downstream raw materials:

3-[1-(3-aminopropyl)indole-3-yl]-4-(1-methylindole-3-yl)-1H-pyrrole-2,5-dione

3-{1-[3-(amidinothio)propyl]-3-indolyl}-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulfonate

3-[1-(3-hydroxy-propyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione

Refernces