Cyclopentaneacetic acid, 3-oxo-a-(phenylthio)-, methyl ester

Base Information

• Chemical Name: Cyclopentaneacetic acid, 3-oxo-a-(phenylthio)-, methyl ester
• CAS No.: 125442-80-0
• Molecular Formula: C14H16O3S
• Molecular Weight: 264.345
• Mol file: 125442-80-0.mol

Synonyms:

Chemical Property of Cyclopentaneacetic acid, 3-oxo-a-(phenylthio)-, methyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentaneacetic acid, 3-oxo-a-(phenylthio)-, methyl ester

There total 1 articles about Cyclopentaneacetic acid, 3-oxo-a-(phenylthio)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

cyclopent-2-enone (930-30-3) + methyl (phenylsulfanyl)acetate (17277-58-6) → (3-Oxo-cyclopentyl)-phenylsulfanyl-acetic acid methyl ester (125442-80-0)

Guidance literature:

With 18-crown-6 ether; potassium tert-butylate; In toluene; at -78 ℃;

DOI:10.1016/S0040-4039(00)88481-6

Reference yield: 86.0%

(3-Oxo-cyclopentyl)-phenylsulfanyl-acetic acid methyl ester (125442-80-0) → methylester of 3-oxo-cyclopentylacetic acid (34130-51-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 0.666667h; Heating;

DOI:10.1016/S0040-4039(00)88481-6

Reference yield:

((R)-3-Oxo-cyclopentyl)-phenylsulfanyl-acetic acid methyl ester (125442-80-0) → (R)-(+)-methyl 3-oxocyclopentylacetate (84621-34-1) + (S)-(-)-methyl 3-oxocyclopentylacetate (2630-38-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

upstream raw materials:

cyclopent-2-enone

methyl (phenylsulfanyl)acetate

Downstream raw materials:

methylester of 3-oxo-cyclopentylacetic acid

Benzenesulfinyl-(3-oxo-cyclopentyl)-acetic acid methyl ester

(R)-(+)-methyl 3-oxocyclopentylacetate

(S)-(-)-methyl 3-oxocyclopentylacetate