(2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone

Base Information

Chemical Name:(2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone
CAS No.:126149-53-9
Molecular Formula:C15H12FNO
Molecular Weight:241.265
Hs Code.:
DSSTox Substance ID:DTXSID30577073
Wikidata:Q82466992
Mol file:126149-53-9.mol

Synonyms:126149-53-9;7-(2-fluorobenzoyl)indoline;SCHEMBL9121111;(2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone;DTXSID30577073;methanone,(2,3-dihydro-1h-indol-7-yl)(2-fluorophenyl)-;PXRIJARNJIAUMV-UHFFFAOYSA-N

Suppliers and Price of (2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:241.090292168
Heavy Atom Count:18
Complexity:320

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC2=C1C=CC=C2C(=O)C3=CC=CC=C3F

Technology Process of (2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone

There total 1 articles about (2,3-Dihydro-1H-indol-7-yl)(2-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496-15-1
1-indoline

: 394-47-8
2-fluorobenzonitrile

: 126149-53-9
7-(2-fluorobenzoyl)-indoline

Guidance literature:: With hydrogenchloride; aluminium trichloride; boron trichloride; Yield given. Multistep reaction; 1.) toluene, reflux, 16 h, 2.) toluene, reflux, 2.5 h;
DOI:10.1248/cpb.42.2071

Reference yield: 96.0%

: 598-21-0
2-Bromoacetyl bromide

: 126149-53-9
7-(2-fluorobenzoyl)-indoline

: 126149-60-8
1-(bromoacetyl)-7-(2-Fluorobenzoyl)indoline

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1248/cpb.42.2071

Reference yield:

: 126149-53-9
7-(2-fluorobenzoyl)-indoline

: 167357-51-9
(3R)-3-amino-5-(2-fluorophenyl)-3,4,6,7-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine

2.1: t-BuOK; iAmONO / tetrahydrofuran

3.1: H₂ / Ru/C / methanol / 3000.24 Torr

3.2: N-Ac-Phe-OH

With pyridine; potassium tert-butylate; hydrogen; isopentyl nitrite; Ru-carbon; In tetrahydrofuran; methanol; 1.1: Cyclocondensation / 2.1: Nitrosation / 3.1: Reduction / 3.2: Racemate separation;
DOI:10.1016/S0960-894X(99)00573-9